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20 Best Tick And Flea Prevention For Dogs (2023 Updated)

There are many tick and flea prevention products available for dogs. Some are topical treatments that are applied to the dog’s skin, while others are oral medications. Some products protect against both ticks and fleas, while others only protect against one or the other.

The best tick and flea prevention product for your dog will depend on your dog’s individual needs and preferences.

20 Best Tick And Flea Prevention For Dogs

Product Image Product Name Features Price

PetArmor Plus Flea, Tick & Lice Treatment, for Dogs & Puppies 4-22 lbs

  • Contains the #1 vet-recommended active ingredient, fipronil and (s)-methoprene, the same active ingredients used in FRONTLINE Plus

PetArmor Plus Flea and Tick Treatment for Large Dogs (45-88 Pounds) 6 Count

  • FAST ACTNG LONG-LASTING FLEA AND TICK PROTECTION: One application of PetArmor Plus lasts up to 30 days nose to tail. A 6-dose package lasts up to six

Advantage II Flea Treatment for Small Dogs, 4 Monthly Treatments, Size: 3-10lb, White

  • 3-10 lbs

Frontline Plus Flea, Tick & Lice Killer, for Dogs – 3 doses

  • 0.02 oz

Petarmor Plus Flea Tick Treatment for Dogs – 6 count

  • Kills fleas, flea eggs, flea larvae, ticks and chewing lice for up to 30 days
  • Stops the flea life cycle and kills flea eggs and larvae for up to 12 weeks

K9 Advantix II Flea and Tick Prevention for Small Dogs, 4-10 Pounds

  • 2 monthly applications of K9 Advantix II flea and tick prevention for small dogs weighing 4-10 pounds
  • K9 Advantix II flea and tick prevention for dogs works through contact, so fleas, ticks and mosquitoes do not have to bite your dog to die

Advantix II – for Dogs 11-20 lbs – 4 Pack

  • Kills fleas on dogs within 12 hours
  • Kills fleas before they lay eggs
  • Kills the flea larvae stage in the dog’s surroundings following contact by a treated dog

Bayer Advantage II for Extra Large Dogs – 4 pack

  • Over 55 lb

Frontline Plus Flea & Tick for Dogs, Up to 22 lbs, 3 Doses

  • 11-22 lbs

Seresto Flea & Tick Collar for Small Dogs, 8 Month Prevention

  • Provides 8-months of continuous flea and tick prevention
  • Seresto flea and tick collar for small dogs works through contact, so fleas and ticks do not have to bite your dog to die

Vectra 3D, 3 Doses, 21-55 lbs

  • 21-55 lbs 3 Doses

Nexgard for Dogs 24.1 – 60.0 lbs,3 Month Supply

  • 24.1-60 lbs

Revolution for Dogs

  • Revolution (Brown) for Small Dogs 5-10 kg (10.1 – 20 lbs).
  • Key Benefits.
  • Dosage and Administration.

Simparica Trio 22.1-44 lbs. Dogs, 6 Month Supply

  • 22.1-44 lbs

Bravecto for Dogs – 44-88 lbs (1 Chew)

  • Simple to give chewable tablet.
  • Safe in breeding, pregnant and lactating dogs.

Comfortis Chewable Tablets for Dogs & Cats, 140 mg – 6 count

  • Comfortis comes in a convenient, beef-flavored chewable
  • Starts to kill fleas within 30 minutes and protection lasts an entire month
PetArmor Plus Flea, Tick & Lice Treatment, for Dogs & Puppies 4-22 lbs
  • Contains the #1 vet-recommended active ingredient, fipronil and (s)-methoprene, the same active ingredients used in FRONTLINE Plus
PetArmor Plus Flea and Tick Treatment for Large Dogs (45-88 Pounds) 6 Count
  • FAST ACTNG LONG-LASTING FLEA AND TICK PROTECTION: One application of PetArmor Plus lasts up to 30 days nose to tail. A 6-dose package lasts up to six
Advantage II Flea Treatment for Small Dogs, 4 Monthly Treatments, Size: 3-10lb, White
  • 3-10 lbs
Frontline Plus Flea, Tick & Lice Killer, for Dogs – 3 doses
  • 0.02 oz
Petarmor Plus Flea Tick Treatment for Dogs – 6 count
  • Kills fleas, flea eggs, flea larvae, ticks and chewing lice for up to 30 days
  • Stops the flea life cycle and kills flea eggs and larvae for up to 12 weeks
K9 Advantix II Flea and Tick Prevention for Small Dogs, 4-10 Pounds
  • 2 monthly applications of K9 Advantix II flea and tick prevention for small dogs weighing 4-10 pounds
  • K9 Advantix II flea and tick prevention for dogs works through contact, so fleas, ticks and mosquitoes do not have to bite your dog to die
Advantix II – for Dogs 11-20 lbs – 4 Pack
  • Kills fleas on dogs within 12 hours
  • Kills fleas before they lay eggs
  • Kills the flea larvae stage in the dog’s surroundings following contact by a treated dog
Bayer Advantage II for Extra Large Dogs – 4 pack
  • Over 55 lb
Frontline Plus Flea & Tick for Dogs, Up to 22 lbs, 3 Doses
  • 11-22 lbs
Seresto Flea & Tick Collar for Small Dogs, 8 Month Prevention
  • Provides 8-months of continuous flea and tick prevention
  • Seresto flea and tick collar for small dogs works through contact, so fleas and ticks do not have to bite your dog to die
Vectra 3D, 3 Doses, 21-55 lbs
  • 21-55 lbs 3 Doses
Nexgard for Dogs 24.1 – 60.0 lbs,3 Month Supply
  • 24.1-60 lbs
Revolution for Dogs
  • Revolution (Brown) for Small Dogs 5-10 kg (10.1 – 20 lbs).
  • Key Benefits.
  • Dosage and Administration.
Simparica Trio 22.1-44 lbs. Dogs, 6 Month Supply
  • 22.1-44 lbs
Bravecto for Dogs – 44-88 lbs (1 Chew)
  • Simple to give chewable tablet.
  • Safe in breeding, pregnant and lactating dogs.
Comfortis Chewable Tablets for Dogs & Cats, 140 mg – 6 count
  • Comfortis comes in a convenient, beef-flavored chewable
  • Starts to kill fleas within 30 minutes and protection lasts an entire month

1. Seresto Flea and Tick Prevention Collar for Large Dogs, 8 Month Prevention, 1.6 oz

Seresto Flea and Tick Prevention Collar for Large Dogs, 8 Month Prevention, 1.6 oz

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Specifications

Details
Product Form Solid
Animal Type Dog
Concentrated No
Product Type Flea and Tick Collar
Odorless Yes
Container Size 1.6 oz
Active Ingredient Imidacloprid/Flumethrin
Application Large dogs 7 weeks and older
Number in Package 1 pk
Recommended Dog Age For Dogs Above 18 lb.
Brand Name Bayer

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2. PetArmor Plus Flea, Tick & Lice Treatment, for Dogs & Puppies 4-22 lbs

PetArmor Plus Flea, Tick & Lice Treatment, for Dogs & Puppies 4-22 lbs

  • Contains the #1 vet-recommended active ingredient, fipronil and (s)-methoprene, the same active ingredients used in FRONTLINE Plus
  • Kills fleas, flea eggs, flea larvae, ticks and chewing lice for up to 30 days
  • Stops the flea life cycle and kills flea eggs and larvae for up to 12 weeks
  • Kills ticks that may transmit Lyme disease
  • Pet Armor Plus – Waterproof. The item does not have an expiration date

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Product Details

Specifications

Details
Units in Package 3
Unit Size 0.023 fl oz applicators
Directions Read entire label before each use. Use only on dogs and puppies over 8 weeks of age. Directions for Use: It is a violation of Federal law to use this product in a manner inconsistent with its labeling. Do not allow children to apply product. To prevent harm to you and your dog, read entire label before each use. Follow all directions and precautionary statements carefully. Do not use on cats, rabbits or animals other than dogs. Do not allow your dog to ingest this product. Do not use on puppies under 8 weeks of age or less than 4 lbs. Use entire contents of tube on each dog. Do not split one tube between dogs. Do not use multiple tubes on one dog. Weigh your dog to be sure you are applying the right dose formulated for the weight of your dog. Separate the treated dog from all other dogs and cats for 24 hours after treatment has been applied. How to Open: Remove product tubes from the package. Separate one tube from the others. Hold the tube with notched end pointing up and away from the face and body. Use scissors to cut off the narrow end at the notches along the line. How to Apply: Invert tube over dog and use open end to part dog’s hair. Squeeze tube firmly to apply all of the solution to the dog’s skin, as directed below. Do not apply more often than once every 4 weeks. Only for Dogs Weighing 4-22 lbs. Do not apply to dogs weighing less than 4 lbs. Apply one tube (0.023 fl oz)(0.67 ml) as a spot to the dog’s back between the shoulder blades. Frequency of Application: Use this product monthly for complete control of flea, tick, and chewing lice infestations. Studies show that this product kills adult fleas for up to three months. Apply monthly if your dog is at high risk for flea reinfestation. Apply monthly to control ticks and chewing lice. This product remains effective even after bathing, water immersion, or exposure to sunlight. Allow treated area to dry thoroughly. Do not reapply for thirty (30) days. Storage and Disposal: Pesticide Storage: Do not remove tube from the pack until ready to use. Store in a cool (below 77 degrees F/25 degrees C), dry place inaccessible to children and pets. Do not refrigerate. Protect from direct sunlight. Container Disposal: If Empty: Non-refillable container. Do not reuse or refill this container. Offer for recycling if available. If Partly Filled: Call your local solid waste agency for disposal instructions. Never place unused product down any indoor or outdoor drain.
Ingredients Active Ingredients: Fipronil (9.80%), (S)-Methoprene (8.80%), Other Ingredient: (81.40%).
Warnings Do not use on cats. Keep out of reach of children. Caution: See back label for additional precautionary statements. Precautionary Statements: Hazards to humans. Caution. Harmful if swallowed. Causes eye irritation. Avoid contact with skin, eyes or clothing. Wash hands thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco or using the toilet. Hazards to Domestic Animals: For external use on dogs only. Individual sensitivities, while rare, may occur after using any pesticide product on dogs. Certain medications can interact with pesticides. Do not treat your dog with more than one pesticide product at a time. Over dosing your dog can result in serious illness and even death. Consult a veterinarian before using on medicated, debilitated, aged, pregnant or nursing dogs. Consult a veterinarian before using on dogs with known organ dysfunction. If your dog is exhibiting signs of and/or is being treated for skin dermatitis, talk to your veterinarian before applying any topical flea and tick control product. First Aid: If Swallowed: Call a poison control center or a doctor immediately for treatment advice. Have person sip a glass of water if able to swallow. Do not induce vomiting unless told to do so by a poison control center or doctor. Do not give anything by mouth to an unconscious person. If in Eyes: Flush eyes with plenty of water. Call a doctor if irritation persists. If on Skin: Wash with plenty of soap and water. Get medical attention if irritation persists. Hot Line Number: Have the product container or label with you when calling a poison control center or doctor, or going for treatment. You may also contact 1-888-908-Tick (8425) for emergency medical treatment information. Side Effects: Monitor your dog after application. Some dogs may experience temporary startle effects when any product is applied. Dogs may experience some temporary irritation at the site of product application such as redness, scratching or other signs of discomfort. If signs of sensitivity occur, bathe your dog with a mild soap and rinse with large amounts of water. If these or other side effects occur, consult your veterinarian or call 1-888-908-Tick (8425). If your dog has an unusual reaction to the initial application, consult a veterinarian before repeating application. The most common signs of incidental ingestion are excessive salivation and foaming at the mouth. If these symptoms occur, immediately feed your dog and continue to monitor your dog for the next 24 hours. Do not use on cats. Keep cats away from treated dogs for 24 hours. If applied to a cat or ingested by a cat, contact your veterinarian.

3. PetArmor Plus Flea and Tick Treatment for Large Dogs (45-88 Pounds) 6 Count

PetArmor Plus Flea and Tick Treatment for Large Dogs (45-88 Pounds) 6 Count

  • FAST ACTNG LONG-LASTING FLEA AND TICK PROTECTION: One application of PetArmor Plus lasts up to 30 days nose to tail. A 6-dose package lasts up to six
  • EASY-TO-USE
  • EFFECTIVE, WATERPROOF FLEA TREATMENT FOR DOGS: PetArmor Plus is a waterproof, flea & tick topical prevention for dogs that kills fleas, flea eggs
  • BREAK THE FLEA CYCLE: Unlike other flea and tick treatments that may temporarily suppress flea activity
  • TRUSTED, VET QUALITY FORMULA: Containing fipronil and (S)-methoprene

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Product Details

Specifications

Details
Animal Type Dog
Breed Size Large
Effective Time Period 30 days
Manufacturer Brand PetArmor
Packaged Height 5.74 in

4. Advantage II Flea Treatment for Small Dogs, 4 Monthly Treatments, Size: 3-10lb, White

Advantage II Flea Treatment for Small Dogs, 4 Monthly Treatments, Size: 3-10lb, White

  • 3-10 lbs

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Product Details

Specifications

Details
Product Form Liquid
Animal Type Dog
Product Type Flea Drops
Concentrated No
Active Ingredient Imidacloprid/Pyriproxyfen

5. Frontline Plus Flea, Tick & Lice Killer, for Dogs – 3 doses

Frontline Plus Flea, Tick & Lice Killer, for Dogs - 3 doses

  • Stops flea infestation
  • Kills adult fleas ticks flea eggs and larvae
  • Prevents all flea stages (eggs larvae pupae) from developing
  • Kills ticks that may transmit diseases
  • Provides waterproof effectiveness

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Product Details

Specifications

Details
Units in Package 3
Directions See insert for first aid and precautionary statements. It is a violation of Federal Law to use this product in a manner inconsistent with its labeling. Do not allow children to apply product. To prevent harm to you and your pet, read entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully. Use on dogs only. Do not use on rabbits. Do not use on other animals. To kill fleas, flea eggs & larvae, ticks, and chewing lice apply Frontline Plus for Dogs as follows: To Remove Applicator: Lift and remove the plastic tab to expose foil backing; then peel away the foil. Or use scissors to open. Open applicator. Hold upright with foil side toward you and snap applicator tip. Apply Frontline Plus. Part the dog’s hair between the shoulder blades. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the animal’s skin. Do not apply on top of the hair coat. Avoid contact with treated area until dry. Frontline Plus is approved for use on all dogs, including breeding, pregnant, and lactating bitches and puppies as young as 8 weeks. Frontline Plus remains effective even after bathing, water immersion, or exposure to sunlight. Frequency of Application: When used monthly, Frontline Plus completely breaks the flea life cycle and controls tick and chewing lice infestations. Do not reapply Frontline Plus for 30 days. Frontline Plus kills adult fleas, flea eggs, and flea larvae for up to three months. Frontline Plus also prevents development of all flea stages for up to three months. Frontline Plus can control fleas for up to three months, however, if there is a high risk of reinfestation or if the pet has fleas which may cause flea allergy dermatitis, a once monthly application may be needed. Frontline Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. Frontline Plus kills all life stages of ticks (larva, nymph and adult). Frontline Plus kills ticks that may transmit Lyme disease, Rocky Mountain spotted fever, ehrlichiosis, babesiosis, anaplasmosis and other tick-borne diseases. Frontline Plus kills chewing lice for at least one month. A once monthly application is recommended where chewing lice control is needed. Frontline Plus aids in the control of sarcoptic mange infestations. Multiple monthly treatments are recommended for the elimination of mites.
Ingredients Active Ingredients: Fipronil (9.8%), (S)-Methoprene (8.8%). Inert Ingredients: (81.4%).
Warnings Keep out of reach of children.

6. PetArmor 45 to 88 lbs Large Plus Flea & Tick Prevention for Dogs – 8 ct

PetArmor 45 to 88 lbs Large Plus Flea & Tick Prevention for Dogs - 8 ct

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Details
Assembled Product Weight 0.2 lb
Animal Type Dog
Assembled Product Dimensions (L x W x H) 6.75 x 1.33 x 5.74 Inches

7. Petarmor Plus Flea Tick Treatment for Dogs – 6 count

Petarmor Plus Flea Tick Treatment for Dogs - 6 count

  • Kills fleas, flea eggs, flea larvae, ticks and chewing lice for up to 30 days
  • Stops the flea life cycle and kills flea eggs and larvae for up to 12 weeks
  • Kills ticks that may transmit Lyme disease
  • For use on dogs 8 weeks of age and over, 4-22 lbs
  • Easy-to-apply squeeze-on treatment

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Details
Country of Origin Made in USA
Animal Type Dog
Breed Size Small
Effective Time Period 30 days
Manufacturer Brand PetArmor

8. Seresto 8 Month Flea & Tick Prevention Collar for Large Dogs 2 Count

Seresto 8 Month Flea & Tick Prevention Collar for Large Dogs 2 Count

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Product Details

Specifications

Details
Product Length 5 inches
Active Ingredient(s) Flumethrin 4.5 Pct., Imidacloprid 10%
Age/Weight Restrictions 7 weeks and older
Medication Type Non-Prescription
Number of Doses 2
Pet Size Large Dog
Pet Type Dog
Pet Weight Range 18lbs and over
Product Width 3.125 inches
Targeted Insect(s) Fleas and Ticks

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9. K9 Advantix II Flea and Tick Prevention for Small Dogs, 4-10 Pounds

K9 Advantix II Flea and Tick Prevention for Small Dogs, 4-10 Pounds

  • 2 monthly applications of K9 Advantix II flea and tick prevention for small dogs weighing 4-10 pounds
  • K9 Advantix II flea and tick prevention for dogs works through contact, so fleas, ticks and mosquitoes do not have to bite your dog to die
  • K9 Advantix II flea and tick control for dogs is an easy to apply topical formula
  • Starts working to kill fleas within 12 hours and keeps working for 30 days
  • Suitable for effective year-round dog flea and tick treatment for small dogs

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Details
Dimensions 1×3.8×5.8 inches

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10. Advantix II – for Dogs 11-20 lbs – 4 Pack

Advantix II - for Dogs 11-20 lbs - 4 Pack

  • Kills fleas on dogs within 12 hours
  • Kills fleas before they lay eggs
  • Kills the flea larvae stage in the dog’s surroundings following contact by a treated dog
  • Kills reinfesting fleas in 2 hours

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Details
Assembled Product Weight 1 lbs

11. Seresto Flea & Tick Collar for Cats, 8 Month Prevention

Seresto Flea & Tick Collar for Cats, 8 Month Prevention

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12. Bayer Advantage II for Extra Large Dogs – 4 pack

Bayer Advantage II for Extra Large Dogs - 4 pack

  • Over 55 lb

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Specifications

Details
Brand Name Bayer
Product Form Liquid
Animal Type Dog
Product Type Flea Drops
Odorless Yes

13. Frontline Plus Flea & Tick for Dogs, Up to 22 lbs, 3 Doses

Frontline Plus Flea & Tick for Dogs, Up to 22 lbs, 3 Doses

  • 11-22 lbs

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Product Details

Specifications

Details
Units in Package 3
Unit Size 0.023 fl oz applicators
Directions It is a violation of Federal Law to use this product in a manner inconsistent with its labeling. Do not allow children to apply product. To prevent harm to you and your pet read entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully use on dogs only. Do not use on rabbits. Do not use on other animals. To kill fleas, all stages of brown dog ticks, American dog ticks, lone star ticks, and deer ticks (which may carry Lyme disease) and chewing lice, apply to dogs or puppies (8 weeks or older) as follows: Remove applicator from child-resistant package. Hold applicator upright and snap applicator tip away from face and body. Place applicator tip through animal’s hair to the skin level between the shoulder blades. Squeeze applicator, applying entire contents in a single spot to the animal’s skin. Avoid superficial application to the animal’s hair. Only one applicator per treatment is needed. Frontline Plus aids in the control of sarcoptic mange infestations. Multiple monthly treatments are recommended for the elimination of mites. Frontline Plus for Dogs can also be used for the treatment and control of flea, tick and chewing lice infestations on breeding, pregnant and lactating bitches. Frequency of Application: When used monthly, Frontline Plus for Dogs completely breaks the flea life cycle and controls tick and chewing lice infestations. Research demonstrates that Frontline Plus kills adult fleas, flea eggs, and flea larvae for up to three months. Frontline Plus also prevents development of all flea stages for up to three months. Although Frontline Plus can control fleas for up to three months, if there is a high risk of reinfestation or if the pet has fleas which may cause flea allergy dermatitis, a once monthly application may be needed. Frontline Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. Frontline Plus kills chewing lice for at least one month. A once monthly application is recommended where chewing lice control is needed. For animal use only.
Ingredients Active Ingredients: Fipronil (9.8%), (S)-Methoprene (8.8%), Inert Ingredients: (81.4%).
Warnings Keep out of reach of children.

14. Seresto Flea & Tick Collar for Small Dogs, 8 Month Prevention

Seresto Flea & Tick Collar for Small Dogs, 8 Month Prevention

  • Provides 8-months of continuous flea and tick prevention
  • Seresto flea and tick collar for small dogs works through contact, so fleas and ticks do not have to bite your dog to die
  • Veterinarian-recommended flea and tick prevention for dogs in a convenient, odorless non-greasy collar; No need for messy monthly treatments

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Redpost Equestrian

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Season Core

15. Vectra 3D, 3 Doses, 21-55 lbs

Vectra 3D, 3 Doses, 21-55 lbs

  • 21-55 lbs 3 Doses

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Details
Assembled Product Weight 0.1500 lb
Assembled Product Dimensions (L x W x H) 5.13 x 5.25 x 1.00 Inches

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16. Nexgard for Dogs 24.1 – 60.0 lbs,3 Month Supply

Nexgard for Dogs 24.1 - 60.0 lbs,3 Month Supply

  • 24.1-60 lbs

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17. Revolution for Dogs

Revolution for Dogs

  • 10.1-20 lbs, 6 Month

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18. Simparica Trio 22.1-44 lbs. Dogs, 6 Month Supply

Simparica Trio 22.1-44 lbs. Dogs, 6 Month Supply

  • 22.1-44 lbs

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Product Details

Specifications

Details
For Use With Dogs
Administration Form Oral
Breed Size Extra Small Breeds
Product Form Chewable Tablet
Drug Type Parasiticide

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19. Bravecto for Dogs – 44-88 lbs (1 Chew)

Bravecto for Dogs - 44-88 lbs (1 Chew)

  • Simple to give chewable tablet.
  • Safe in breeding, pregnant and lactating dogs.

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Specifications

Details
For Use With Dogs 44-88 lbs. Do not use on dogs under 44 lbs
Administration Form Oral
Breed Size Medium Breeds, Large Breeds
Product Form Chew
Strength 1000 mg Fluralaner
Drug Type Parasiticide

20. Comfortis Chewable Tablets for Dogs & Cats, 140 mg – 6 count

Comfortis Chewable Tablets for Dogs & Cats, 140 mg - 6 count

  • Comfortis comes in a convenient, beef-flavored chewable
  • Starts to kill fleas within 30 minutes and protection lasts an entire month
  • Spinosad, the active ingredient in Comfortis, is environmentally friendly

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Product Details

Specifications

Details
Primary Brand Comfortis
For Pet Weight Max 10 LBS
For Pet Weight Min 4.1 LBS

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Conclusion

The best way to protect your dog from fleas and ticks is to use a monthly preventative, like Frontline or Advantix. Be sure to follow the directions on the package, and apply the preventative on a day when your dog will not be swimming or bathing, as this can make the product less effective.

You should also check your dog for fleas and ticks regularly, especially if they spend time outdoors. If you find a flea or tick on your dog, use a flea comb to remove it, and then dispose of the flea or tick in a sealed bag.

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