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20 Best Preservative Free Eye Drops For Dry Eyes (2022 Updated)

There are a number of reasons why you might want to use preservative free eye drops for dry eyes. For one, preservatives can be irritating to the eye, so using a preservative free product can help to reduce irritation.

Additionally, if you have a sensitive reaction to preservatives, using a preservative free product can help to prevent any adverse reactions. Finally, if you are using eye drops more frequently, you may want to consider using a preservative free product to help reduce the risk of any build-up of preservatives in the eye.

20 Best Preservative Free Eye Drops For Dry Eyes

Product Image Product Name Features Price

FRESHKOTE Preservative Free Lubricant Eye Drops

  • These lubricant eye drops help reduce discomfort caused by dry eyes
  • Its advanced composition helps soothe irritation in the eyes

Refresh Plus Lubricant Eye Drops, Preservative-Free, 0.01 fl oz Single-Use Containers, 50 Count, Packaging May Vary

  • Instantly moisturizes and relieves dry, burning, irritated eyes
  • Fast-Acting, long-lasting
  • Formula has many of the same healthy qualities as your own natural tears

35 Vials Oasis Tears Preservative-Free Lubricant Eye Drops

  • Recommended for the relief of moderate to severe dry eye symptoms
  • For day or night time use
  • Preservative-free

Alcon Bion Tears Eye Drops, Lubricant, Severe Dry Eye, Single-Use Vials – 28 pack …

  • Relieves dryness of the eye.
  • Temporarily relieves the burning and irritation from dry eyes.
  • Mimics the composition of human tears.

Refresh Plus Lubricant Single-Use Eye Drops – 30 ct, 0.01 fl oz vials

  • Infusion of essential ingredients assists in moisturizing your dry eyes
  • Its advanced composition helps soothe irritation in the eyes

Bausch + Lomb Soothe XP 30-Count Preservative Free Lubricant Eye Drops

  • Preservative-free lubricant drops moisturize your eyes to help relieve dryness
  • Restoryl mineral oils assist in preventing irritation in your eyes

Systane Eye Drops, Lubricant, Hydration PF – 30 pack, 0.7 ml vials

  • Systane hydration eye drops also help to regenerate damaged cells on the surface of the eye.
  • Systane hydration drops are suitable for providing temporary relief from burning and irritation caused by dry eyes.

Optase Dry Eye Drops, Intense, Sterile – 0.33 fl oz

  • Preservative free and Phosphate free for frequent use without irritation.
  • Advanced long-lasting formulation for comfort and relief.

Oasis Tears Plus Lubricant Eye Drops Preservative-Free 30 Containers, 0.3 ml/0.01 fl oz

  • Enriched with glycerin to help moisten your dry eyes to reduce irritation
  • Preservative-free formula helps make it suitable for daily usage

Similasan iVizia Eye Drops, Lubricant, Sterile, For Dry Eyes – 0.16 fl oz

  • 0.16 Fl Oz

Bausch + Lomb Soothe Lubricant Eye Drops, Preservative Free – 30 vials, 0.02 fl oz

  • These liquid drops help restore your eyes natural balance
  • Moisturize your eyes with these eye drops
  • It helps soothe irritated eyes and provides long-lasting relief

Systane Ultra Lubricant Eye Drops 60

  • 60 Ct

Systane Eye Drops, Lubricant, Preservative-Free Vials – 28 pack, 0.01 fl oz vials

  • Soothing comfort
  • Long lasting relief
  • Dry eye therapy

Clinitas Perservative Free Lubricant Eye Drops 30 x 0.5mL

  • Low-blink rate activities due to computer use, TV watching, driving and reading.
  • Lachrymal insufficiency.
  • Sensitivity to preservatives When applied as eye drops it forms a transparent film that coats the surface of the eyeball.

Oasis Tears PF Preservative-Free Lubricant Eye Drops Relief

  • Preservative-free formula makes it safe for daily usage
  • Developed to moisten and lubricate to subside the dry eye disease symptoms

Refresh Optive Lubricant Eye Drops – 30 pack, 0.01 fl oz vials

  • Preservative-Free
  • Moisturizing Dry Eye Solution
  • Recommended for LASIK Dryness

FRESHKOTE Preservative Free (Pf) Lubricant Eye Drops (Pack of 2)

  • Temporary relief from symptoms of dry eye.
  • Unique phospholipid blend combats tear evaporation.
  • Gentle, preservative-free drops can be used with contact lenses.
FRESHKOTE Preservative Free Lubricant Eye Drops
  • These lubricant eye drops help reduce discomfort caused by dry eyes
  • Its advanced composition helps soothe irritation in the eyes
Refresh Plus Lubricant Eye Drops, Preservative-Free, 0.01 fl oz Single-Use Containers, 50 Count, Packaging May Vary
  • Instantly moisturizes and relieves dry, burning, irritated eyes
  • Fast-Acting, long-lasting
  • Formula has many of the same healthy qualities as your own natural tears
35 Vials Oasis Tears Preservative-Free Lubricant Eye Drops
  • Recommended for the relief of moderate to severe dry eye symptoms
  • For day or night time use
  • Preservative-free
Alcon Bion Tears Eye Drops, Lubricant, Severe Dry Eye, Single-Use Vials – 28 pack …
  • Relieves dryness of the eye.
  • Temporarily relieves the burning and irritation from dry eyes.
  • Mimics the composition of human tears.
Refresh Plus Lubricant Single-Use Eye Drops – 30 ct, 0.01 fl oz vials
  • Infusion of essential ingredients assists in moisturizing your dry eyes
  • Its advanced composition helps soothe irritation in the eyes
Bausch + Lomb Soothe XP 30-Count Preservative Free Lubricant Eye Drops
  • Preservative-free lubricant drops moisturize your eyes to help relieve dryness
  • Restoryl mineral oils assist in preventing irritation in your eyes
Systane Eye Drops, Lubricant, Hydration PF – 30 pack, 0.7 ml vials
  • Systane hydration eye drops also help to regenerate damaged cells on the surface of the eye.
  • Systane hydration drops are suitable for providing temporary relief from burning and irritation caused by dry eyes.
Optase Dry Eye Drops, Intense, Sterile – 0.33 fl oz
  • Preservative free and Phosphate free for frequent use without irritation.
  • Advanced long-lasting formulation for comfort and relief.
Oasis Tears Plus Lubricant Eye Drops Preservative-Free 30 Containers, 0.3 ml/0.01 fl oz
  • Enriched with glycerin to help moisten your dry eyes to reduce irritation
  • Preservative-free formula helps make it suitable for daily usage
Similasan iVizia Eye Drops, Lubricant, Sterile, For Dry Eyes – 0.16 fl oz
  • 0.16 Fl Oz
Bausch + Lomb Soothe Lubricant Eye Drops, Preservative Free – 30 vials, 0.02 fl oz
  • These liquid drops help restore your eyes natural balance
  • Moisturize your eyes with these eye drops
  • It helps soothe irritated eyes and provides long-lasting relief
Systane Ultra Lubricant Eye Drops 60
  • 60 Ct
Systane Eye Drops, Lubricant, Preservative-Free Vials – 28 pack, 0.01 fl oz vials
  • Soothing comfort
  • Long lasting relief
  • Dry eye therapy
Clinitas Perservative Free Lubricant Eye Drops 30 x 0.5mL
  • Low-blink rate activities due to computer use, TV watching, driving and reading.
  • Lachrymal insufficiency.
  • Sensitivity to preservatives When applied as eye drops it forms a transparent film that coats the surface of the eyeball.
Oasis Tears PF Preservative-Free Lubricant Eye Drops Relief
  • Preservative-free formula makes it safe for daily usage
  • Developed to moisten and lubricate to subside the dry eye disease symptoms
Refresh Optive Lubricant Eye Drops – 30 pack, 0.01 fl oz vials
  • Preservative-Free
  • Moisturizing Dry Eye Solution
  • Recommended for LASIK Dryness
FRESHKOTE Preservative Free (Pf) Lubricant Eye Drops (Pack of 2)
  • Temporary relief from symptoms of dry eye.
  • Unique phospholipid blend combats tear evaporation.
  • Gentle, preservative-free drops can be used with contact lenses.

1. FRESHKOTE Preservative Free Lubricant Eye Drops

FRESHKOTE Preservative Free Lubricant Eye Drops

  • Relieves burning and irritation
  • For dryness of the eye

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Amazon.com – Seller
DryEye Rescue
Sears – zabiva

Product Details

Specifications

Details
Is Discontinued By Manufacturer No
Package Dimensions 3.19 x 1.18 x 1.14 inches; 1.13 Ounces
Package Information Bottle

2. Refresh Plus Lubricant Eye Drops, Preservative-Free, 0.01 fl oz Single-Use Containers, 50 Count, Packaging May Vary

Refresh Plus Lubricant Eye Drops, Preservative-Free, 0.01 fl oz Single-Use Containers, 50 Count, Packaging May Vary

  • Instantly moisturizes and relieves dry, burning, irritated eyes
  • Fast-Acting, long-lasting
  • Formula has many of the same healthy qualities as your own natural tears
  • Recommended for LASIK dryness
  • No.1 Doctor recommended artificial tear brand

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Amazon.com

Product Details

Specifications

Details
Is Discontinued By Manufacturer No
Product Dimensions 5 x 5 x 5 inches; 0.51 Ounces
Country of Origin USA
Flavor Original
Net Content Count 50 Count

3. 35 Vials Oasis Tears Preservative-Free Lubricant Eye Drops

35 Vials Oasis Tears Preservative-Free Lubricant Eye Drops

  • Recommended for the relief of moderate to severe dry eye symptoms
  • For day or night time use
  • Preservative-free

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Amazon.com – Seller
eBay – coco-tree
goodholidayprice

Product Details

Specifications

Details
Is Discontinued By Manufacturer No
Package Dimensions 7.17 x 3.39 x 1.61 inches; 2.4 Ounces
Use for Eyes
Specific Uses For Product Dry Eyes
Unit Count 35.00 Count

4. Alcon Bion Tears Eye Drops, Lubricant, Severe Dry Eye, Single-Use Vials – 28 pack …

Alcon Bion Tears Eye Drops, Lubricant, Severe Dry Eye, Single-Use Vials - 28 pack ...

  • Relieves dryness of the eye.
  • Temporarily relieves the burning and irritation from dry eyes.
  • Mimics the composition of human tears.
  • Helps restore the eye to its natural environment, making it one of the most effective artificial tea.

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Amazon.com – Seller
eBay
Walmart
EZContacts.com

Product Details

Specifications

Details
Units in Package 28
Unit Size 0.015 fl oz vials
Indications Uses: For use as a protectant against further irritation or to relieve dryness of the eye.
Directions Directions: Make sure container is intact before use. To open, completely twist off tab. Do not pull off. Instill 1 or 2 drops in the affected eye(s) as needed. Throw away container. Do not reuse. Once opened, discard. All four containers within a pouch must be used within four days of opening the pouch. Instill 1 or 2 drops in the affected eye(s) as needed.
Ingredients Active Ingredients: Dextran 70 (0.1%), Hypromellose 2910 (0.3%). Purpose: Lubricant, Lubricant. Inactive Ingredients: Calcium Chloride, Magnesium Chloride, Potassium Chloride, Purified Water, Sodium Bicarbonate, Sodium Chloride, Zinc Chloride, Hydrochloric Acid and/or Sodium Hydroxide and/or Carbon Dioxide to Adjust pH.
Warnings Warnings: For external use only. Do not use: if this solution changes color or becomes cloudy; if you are sensitive to any ingredient in this product. When using this product: to avoid contamination, do not touch tip of container to any surface; do not touch unit-dose tip to eye; do not reuse (Once opened, discard). Stop use and ask a doctor if: you experience eye pain; changes in vision; continued redness; irritation of the eye; symptoms worsening or persisting for more than 72 hours. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away. Other warnings: Tamper Evident: Containers are sealed in a protective foil pouch. Use only if foil pouch is undamaged at time of purchase.

5. Refresh Plus Lubricant Single-Use Eye Drops – 30 ct, 0.01 fl oz vials

Refresh Plus Lubricant Single-Use Eye Drops - 30 ct, 0.01 fl oz vials

  • Infusion of essential ingredients assists in moisturizing your dry eyes
  • Its advanced composition helps soothe irritation in the eyes
  • Eye drop vials offer convenient usage

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Amazon.com
Walmart
Vitacost.com
EZContacts.com

Product Details

Specifications

Details
Product Type Eye drops
Container Type Vial
Purpose Eye lubricant
Recommended Age Group Adult
Preservative-Free Yes

Reviews From Real Customers

dominick.r

6. Oasis Tears Plus Preservative-Free Lubricant Eye Drops 40 Vials (1 Box of 30 Vials Plus Two 5 Vial Packets)

Oasis Tears Plus Preservative-Free Lubricant Eye Drops 40 Vials (1 Box of 30 Vials Plus Two 5 Vial Packets)

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Amazon.com – Seller
Oneway Beauty

Product Details

Specifications

Details
Package Dimensions 7 x 3.1 x 1 inches; 2.89 Ounces

7. Bausch + Lomb Soothe XP 30-Count Preservative Free Lubricant Eye Drops

Bausch + Lomb Soothe XP 30-Count Preservative Free Lubricant Eye Drops

  • Preservative-free lubricant drops moisturize your eyes to help relieve dryness
  • Restoryl mineral oils assist in preventing irritation in your eyes
  • It helps protect the eyes against tear loss

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Amazon.com
Walmart
CVS Pharmacy
Rite Aid

Product Details

Specifications

Details
Product Form Liquid
Preservative-Free Yes
Volume 0.3 ml
Number of Drops 30

Reviews From Real Customers

dzi_93
kaththo87

8. Systane Eye Drops, Lubricant, Hydration PF – 30 pack, 0.7 ml vials

Systane Eye Drops, Lubricant, Hydration PF - 30 pack, 0.7 ml vials

  • Systane hydration eye drops also help to regenerate damaged cells on the surface of the eye.
  • Systane hydration drops are suitable for providing temporary relief from burning and irritation caused by dry eyes.
  • Systane hydration drops can be applied directly to the eye and onto the surface of your contact lenses.

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Amazon.com
Walmart
Target
CVS Pharmacy

Product Details

Specifications

Details
Units in Package 30
Unit Size 0.7 ml vials
Indications Uses: For use as protectant against further irritation or to relieve dryness of the eye.
Directions General directions: Put 1 or 2 drops in the affected eye(s) as needed. Make sure container is intact before use. To open, completely twist off tab. Do not pull off. Put 1 or 2 drops in the affected eye(s) as needed. Throw away container. Do not reuse.
Ingredients Active Ingredients: Polyethylene Glycol 400 (0.4 %), Propylene Glycol (0.3 %). Purpose: Lubricant, Lubricant. Inactive Ingredients: Aminomethylpropanol, Boric Acid, Hydroxypropyl Guar, Potassium Chloride, Purified Water, Sodium Borate, Sodium Chloride, Sodium Hyaluronate, Sorbitol, May Contain Hydrochloric Acid and/or Sodium Hydroxide to Adjust pH

Reviews From Real Customers

MFG

9. Optase Dry Eye Drops, Intense, Sterile – 0.33 fl oz

Optase Dry Eye Drops, Intense, Sterile - 0.33 fl oz

  • Preservative free and Phosphate free for frequent use without irritation.
  • Advanced long-lasting formulation for comfort and relief.
  • Can be used with contact lenses.
  • Advanced bottle technology means it can be used for 3 months after opening.
  • Value for money with 300 drops per bottle.

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Amazon.com – Seller
eBay
Walmart
Walgreens.com

Product Details

Specifications

Details
Units in Package 1
Unit Size 0.33 fl oz
Indications Uses: For use as a lubricant to prevent further irritation. May be used as a protectant against further irritation. To relieve dryness of the eye.
Directions General directions: Put one or two drops in the affected eyes as needed. Put one or two drops in the affected eyes as needed to moisturize and soothe dry, irritated eyes.
Ingredients Active Ingredients: Glycerin (0.2 %). Purpose: Eye Lubricant. Inactive Ingredients: Hydrochloric Acid, Sodium Hyaluronate, Sorbitol, Trometamol, Water

10. Oasis Tears Plus Lubricant Eye Drops Preservative-Free 30 Containers, 0.3 ml/0.01 fl oz

Oasis Tears Plus Lubricant Eye Drops Preservative-Free 30 Containers, 0.3 ml/0.01 fl oz

  • Enriched with glycerin to help moisten your dry eyes to reduce irritation
  • Preservative-free formula helps make it suitable for daily usage
  • Sterile and disposable containers reduce the risk of contamination

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Amazon
eBay
Walmart
DryEye Rescue

Product Details

Specifications

Details
Number of Units 30
Volume per Unit 0.01 fl oz
Product Form Liquid
Disposable Yes
Preservative-Free Yes

11. Similasan iVizia Eye Drops, Lubricant, Sterile, For Dry Eyes – 0.16 fl oz

Similasan iVizia Eye Drops, Lubricant, Sterile, For Dry Eyes - 0.16 fl oz

  • 0.16 Fl Oz

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Walmart
CVS Pharmacy

Product Details

Specifications

Details
Units in Package 1
Unit Size 0.16 fl oz
Indications Uses: (one or more of these) For the temporary relief of burning and irritation due to dryness of the eye; For the temporary relief of discomfort due to minor irritations of the eye or to exposure to wind and sun; For use as a protectant against further irritation or to relieve dryness of the eye; For use as a lubricant to prevent further irritation or to relieve dryness of the eye..
Directions General directions: Wash hands well before use. Instill 1 or 2 drops in the affected eye(s) as needed. Can be used when wearing contact lenses. To limit blurriness when using contact lenses: remove contacts, apply drops, then insert contacts.
Ingredients Active Ingredients: Povidone (0.5 %). Purpose: Eye Lubricant. Inactive Ingredients: Hydrochloric Acid, Purified Water, Sodium Chloride, Sodium Hyaluronate, Trehalose, Tromethamine

12. Bausch + Lomb Soothe Lubricant Eye Drops, Preservative Free – 30 vials, 0.02 fl oz

Bausch + Lomb Soothe Lubricant Eye Drops, Preservative Free - 30 vials, 0.02 fl oz

  • These liquid drops help restore your eyes natural balance
  • Moisturize your eyes with these eye drops
  • It helps soothe irritated eyes and provides long-lasting relief

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Amazon
Walmart
CVS Pharmacy
Fred Meyer

Product Details

Specifications

Details
Height 4.2″
Width 2.05″
Length 3.15″
Product Type Eye drops
Preservative-Free Yes

13. Systane Ultra Lubricant Eye Drops 60

Systane Ultra Lubricant Eye Drops 60

  • 60 Ct

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Amazon
Walmart
CVS Pharmacy
Rite Aid

Product Details

Specifications

Details
Purpose Lubricant
Preservative-Free Yes
Product Form Drops
Net Volume 0.7 ml
Net Weight 0.02 oz

14. Oasis Tears Preservative-Free Lubricant Eye Drops

Oasis Tears Preservative-Free Lubricant Eye Drops

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Amazon
eBay – budgetsavers
Walmart – DryEye Rescue
DryEye Rescue

Product Details

Specifications

Details
Assembled Product Weight 0.2 lb
Assembled Product Dimensions (L x W x H) 7.00 x 1.00 x 3.00 Inches

Reviews From Real Customers

kangysue
lilshe-65
sologma

15. Systane Eye Drops, Lubricant, Preservative-Free Vials – 28 pack, 0.01 fl oz vials

Systane Eye Drops, Lubricant, Preservative-Free Vials - 28 pack, 0.01 fl oz vials

  • Soothing comfort
  • Long lasting relief
  • Dry eye therapy
  • Convenient preservative-free vials

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Amazon
AAA Wholesale

Product Details

Specifications

Details
Units in Package 28
Unit Size 0.01 fl oz vials
Indications Uses: For the temporary relief of burning and irritation due to dryness of the eye.
Directions Directions: Instill 1 or 2 drops in the affected eye(s) as needed. Make sure container is intact before use. To open, completely twist off tab. Do not pull off. Throw away container. Do not reuse.
Ingredients Active Ingredients: Polyethylene Glycol 400 (0.4%), Propylene Glycol (0.3%). Purpose: Lubricant, Lubricant. Inactive Ingredients: Boric Acid, Calcium Chloride, Hydroxypropyl Guar, Magnesium Chloride, Potassium Chloride, Purified Water, Sodium Chloride, Zinc Chloride. May Contain Hydrochloric Acid and/or Sodium Hydroxide to Adjust pH.

16. Clinitas Perservative Free Lubricant Eye Drops 30 x 0.5mL

Clinitas Perservative Free Lubricant Eye Drops 30 x 0.5mL

  • Low-blink rate activities due to computer use, TV watching, driving and reading.
  • Lachrymal insufficiency.
  • Sensitivity to preservatives When applied as eye drops it forms a transparent film that coats the surface of the eyeball.

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Amazon
Bonanza – EM Healthcare

Product Details

Specifications

Details
Purchase protection Bonanza Buyer Protection Pledge

Reviews From Real Customers

Reviewed by EasyMeds Pharmacy customer

17. Oasis Tears PF Preservative-Free Lubricant Eye Drops Relief

Oasis Tears PF Preservative-Free Lubricant Eye Drops Relief

  • Preservative-free formula makes it safe for daily usage
  • Developed to moisten and lubricate to subside the dry eye disease symptoms
  • Formulated to relieve from burning, irritation and sensation in your eyes

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Amazon
eBay
Walmart
DryEye Rescue

Product Details

Specifications

Details
Container Type Bottle
Weight 0.34 oz
Preservative-Free Yes
Dispenser Type Dropper
Product Form Liquid

Reviews From Real Customers

SHELLEY
greih.w
herree80

18. Refresh Plus Lubricant Single-Use Eye Drops – 100 ct, 0.01 fl oz vials

Refresh Plus Lubricant Single-Use Eye Drops - 100 ct, 0.01 fl oz vials

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Amazon
Walmart
Sam’s Club
BJ’s Wholesale Club

Product Details

Specifications

Details
Ingredients Active Ingredient: Carboxymethylcellulose Sodium 0.5%…Purpose: Eye Lubricant. Inactive Ingredients: Calcium Chloride, Magnesium Chloride; Potassium Chloride; Purified Water, Sodium Chloride, and Sodium Lactate. May Also Contain Hydrochloric Acid and/Or Sodium Hydroxide to Adjust Ph.
Units in Package 100

19. Refresh Optive Lubricant Eye Drops – 30 pack, 0.01 fl oz vials

Refresh Optive Lubricant Eye Drops - 30 pack, 0.01 fl oz vials

  • Preservative-Free
  • Moisturizing Dry Eye Solution
  • Recommended for LASIK Dryness
  • Store at 59-86F (15-30C)
  • Retain this carton for future reference

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Amazon
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Walmart
Walgreens.com

Product Details

Specifications

Details
Units in Package 30
Unit Size 0.01 fl oz vials
Indications Uses: For the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun. May be used as a protectant against further irritation.
Directions General directions: How to Use: To open, twist and pull tab to remove. Instill 1 or 2 drops in the affected eye(s) as needed and discard container. If used for post-operative (eg LASIK) dryness and discomfort, follow your eye doctor’s instructions.
Ingredients Active Ingredients: Carboxymethylcellulose Sodium (0.5 %), Glycerin (0.9 %). Purpose: Eye Lubricant, Eye Lubricant. Inactive Ingredients: Boric Acid, Calcium Chloride Dihydrate, Erythritol, Levocarnitine, Magnesium Chloride Hexahydrate, Potassium Chloride, Purified Water, Sodium Borate Decahydrate, Sodium Citrate Dihydrate
Warnings For external use only. To avoid contamination, do not touch tip of container to any surface. Do not reuse, once opened, discard. Do not touch unit-dose tip to eye. If solution changes color, do not use. Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

20. FRESHKOTE Preservative Free (PF) Lubricant Eye Drops (Pack of 2)

FRESHKOTE Preservative Free (PF) Lubricant Eye Drops (Pack of 2)

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Amazon
Walmart – DryEye Rescue
DryEye Rescue

Product Details

Specifications

Details
Assembled Product Weight 0.3 lb
Assembled Product Dimensions (L x W x H) 4.00 x 2.00 x 4.00 Inches

Reviews From Real Customers

1908kaye
nyshirl
blackcherrytree

Conclusion

The conclusion of preservative free eye drops for dry eyes is that they are a safe and effective treatment for dry eyes.

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