If you’re looking for a fast and effective way to treat cold sores without a prescription, over-the-counter (OTC) medications are your best bet. With so many products on the market, it can be overwhelming to choose the right one. There are a few important factors to consider before making a decision.
First, it's important to determine whether you prefer a cream or an oral medication. Creams are easy to apply directly to the affected area, while oral medications are easy to swallow and can provide relief for additional symptoms. Second, you should consider the ingredients in the medication. Some OTC medications contain antiviral drugs, such as acyclovir and docosanol, which can help reduce the duration of your cold sore outbreak. Third, the cost of the medication should also be a consideration since prices vary significantly from one product to another.
Are you tired of dealing with painful and unsightly cold sores that take forever to go away? Have you tried multiple treatments with little success? Are you wondering if an OTC medication might be the answer? In this article, you'll learn about the best OTC medicines for cold sores and what factors you need to consider before making a purchase. Keep reading to find out how you can get relief from cold sores quickly and inexpensively.
10 Best Otc Medicine For Cold Sores
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Relieving sore throat pain and discomfort with maximum strength lozenges flavored with wild berries.
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2
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The product is ideal for cold relief with cooling menthol and eucalyptus, in the form of nasal swabs.
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3
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It is ideal for treating symptoms of cold sores.
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4
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This product is ideal for treating cold sores and fever blisters, providing relief in just 2.5 days.
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5
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This product is ideal for treating cold sores and fever blisters.
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6
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Ideal for providing instant relief, preventing infection and promoting healing of cold sores and fever blisters on lips.
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7
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It is ideal for relieving symptoms of cold, cough, nasal and chest congestion, and sore throat in children.
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8
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This product is ideal for providing non-drowsy relief from the symptoms of severe cold and flu in both adults and children over 6 years old.
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9
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It treats and relieves symptoms of cold sores and fever blisters, reducing healing time.
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10
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Theraflu Severe Cold Daytime Relief Powder is ideal for treating symptoms of cold and cough quickly and efficiently.
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1. Chloraseptic Max Strength Sore Throat Lozenges, Wild Berries, 15 Count, 1 Pack

Are you tired of dealing with the discomfort of a sore throat? Look no further than Chloraseptic Max Strength Sore Throat Lozenges. These lozenges are designed to provide fast and effective relief to throat and mouth pain.
The secret to their effectiveness is the soothing liquid center that relieves throat pain and cools nasal passages. This provides maximum strength pain relief for your sore throat without the need for a prescription. The lozenges are fast-acting, so you can feel relief quickly.
Chloraseptic Wild Berries is safe for the whole family, including children ages 6 and up. This trusted brand has been recommended by doctors for 50 years and is known for its effectiveness.
If you're looking for a safe and reliable way to relieve throat pain, Chloraseptic Max Strength Sore Throat Lozenges are the perfect choice. Don't let a sore throat ruin your day – try Chloraseptic today!
2. Zicam Cold Remedy Nasal Swabs With Cooling Menthol & Eucalyptus, 20 Count (Pack Of 1)

Introducing the Homeopathic Nasal Swabs from Zicam – the clinically proven solution to shorten colds when taken at the first sign of sniffles, sneezes, or coughs. This easy-to-use and gentle remedy is a must-have for anyone looking for a simple and effective homeopathic cold remedy.
Our Zinc-Free Cold Remedy Nasal Swabs provide relief from cold symptoms and nasal congestion. It contains cooling menthol and soothing eucalyptus that help you get better faster. With Zicam Cold Remedy, you can go from cold to no cold in no time.
Zicam Cold Remedy products are clinically proven to shorten colds when taken at the first sign, helping you feel better, faster. In addition to the nasal swabs, we also offer a range of products for homeopathic allergy relief, nasal congestion, and sinus relief. Zicam is your one-stop solution for all your homeopathic needs.
Zicam homeopathic cold remedy is meant to be used in the beginning stages of a cold. At the first sniffle, sneeze, or cough of an oncoming cold, try Zicam for shorter colds. We guarantee your satisfaction with our products.
3. Orajel Moisturelock Cold Sore Symptom Treatment, Cream 0.105 Oz (Packaging May Vary)

Looking for instant pain relief and skin protection? Look no further than this powerful skin protectant cream. With maximum strength benzocaine, this cream provides fast-acting relief for a wide range of skin irritations and discomforts. Whether you're dealing with insect bites, minor burns, or other sources of pain, this cream can help soothe and protect your skin.
But that's not all – this cream also includes Moisturelock technology, which helps to seal in moisture and keep your skin hydrated. This can be especially helpful for those with dry or sensitive skin, as it can help prevent further irritation and promote healing.
In addition to its pain-relieving and moisturizing properties, this cream also helps to mask redness. So whether you're dealing with a painful rash or simply want to even out your skin tone, this cream can help you achieve a smoother, more comfortable complexion.
So why wait? If you're looking for a powerful skin protectant that provides instant pain relief and long-lasting hydration, this cream is the perfect choice. Try it today and see the difference for yourself!
4. Quick Relief For Cold Sores – Abreva 10%

The Abreva 10 Percent Docosanol Cold Sore Treatment is a powerful fever blister cream that comes in two 0.07 oz tubes. This product is specially formulated to reduce the duration of cold sore symptoms. In fact, it has been clinically proven to heal cold sores in just 2.5 days (1).
The secret behind this product's exceptional performance is its 10 percent docosanol content. This active ingredient penetrates deep into the skin to tackle cold sores at their source (1, 2, 3). No other cold sore treatment heals fever blisters faster than Abreva.
This lip cream is also clinically proven to shorten the duration of symptoms associated with cold sores, such as tingling, pain, burning, and itching (1). Whether you're experiencing the first signs of a cold sore or are in the midst of an outbreak, Abreva can help you feel better faster.
One of the best things about this cold sore cream is its portability. The product comes packaged in a convenient tube, making it easy to take with you wherever you go. Whether you're traveling, at work, or out with friends, you can always have Abreva on hand for on-the-go cold sore treatment.
5. Abreva Docosanol 10 Percent Cream Cold Sore Treatment, Fever Blister And Cold Sore Cream – 0.07 Oz

This soothing cream is a must-have for anyone who experiences itching and burning. The compact tube is perfect for on-the-go relief and provides temporary relief from discomfort. Its easy-to-apply formula is designed to soothe and calm irritated skin.
This cream has been specifically formulated to provide relief from itching and burning, making it an ideal solution for individuals dealing with discomfort. The portable tube is convenient and easy to carry in a purse or pocket, allowing for quick and discreet application whenever needed.
The unique formula of this cream offers temporary relief from discomfort, making it a great option for individuals seeking fast and effective relief. The cream is easy to apply and can be used as often as needed to provide soothing relief.
6. Instant Relief For Cold Sores: Campho Phenique

This product is designed to provide fast and effective relief for cold sores and fever blisters. Its specialized formula is carefully crafted to soothe pain and itching associated with these conditions. Additionally, it helps to prevent infection and promote healing.
Suitable for adults and children aged 2 years and over, this product is a trusted solution for anyone experiencing the discomfort of cold sores or fever blisters. It should be stored at room temperature for optimal efficacy.
By using this product, users can expect to experience relief from the symptoms of cold sores and fever blisters quickly and easily. Its powerful formula is designed to penetrate deeply to provide fast and effective relief.
7. Mucinex Mixed Berry Liquid For Children's Colds

Mucinex Children's Cold & Flu is a reliable solution for multi-symptom relief, providing comfort from coughing, sore throat, nasal congestion, chest congestion, headache, and minor aches and pains. This over-the-counter medication is designed to ease the discomfort of cold and flu symptoms in children aged six and above.
Mucinex Children's Cold & Flu is the number one pediatrician recommended brand among non-homeopathic children's cough and cold OTC products. It is a safe and effective remedy for children's cold and flu symptoms.
The medication is formulated to provide pain relief and reduce fever with the help of acetaminophen. It is also equipped with dextromethorphan HBr, a cough suppressant that helps control coughs. Guaifenesin, an expectorant, is included in the medication to help thin and loosen mucus and relieve chest congestion. The nasal decongestant Phenylephrine HCl helps relieve nasal congestion, sinus congestion, and pressure.
Mucinex Children's Cold & Flu is available in a Very Berry flavor that kids will love. It is recommended to use this medication as directed and is suitable for children aged six years and above.
8. Flu-Fighter Liquid For Adults & Kids

Amazon Basic Care Severe Cold and Flu Relief is a powerful daytime medicine that temporarily relieves common cold and flu symptoms. It contains four active ingredients that work together to provide fast and effective relief. These active ingredients include acetaminophen, dextromethorphan HBr, guaifenesin, and phenylephrine HCl.
Acetaminophen is a pain reliever and fever reducer that helps ease headache, fever, sore throat, and minor aches and pains associated with the common cold and flu. Dextromethorphan HBr is a cough suppressant that helps to reduce coughing caused by the common cold and flu. Guaifenesin is an expectorant that helps to loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus. Phenylephrine HCl is a nasal decongestant that relieves nasal and sinus congestion and sinus pressure for non-drowsy relief.
This maximum-strength pain reliever and fever reducer is alcohol-free and provides temporary relief from the discomfort caused by cold and flu symptoms. It is specifically designed to relieve headache, fever, sore throat, nasal and sinus congestion, sinus pressure, cough, and chest congestion.
Amazon Basic Care Severe Cold and Flu Relief is also a cough suppressant and expectorant that helps to make coughs more productive. It provides fast and effective relief from common cold and flu symptoms without causing drowsiness.
9. Abreva Cold Sore/fever Blister Treatment.07-Ounce Tube

Abreva is a reliable and effective solution for anyone struggling with cold sores. This product is proudly made in the United States, ensuring the highest quality and safety standards. With its compact and practical design, Abreva is easy to use and store. The item package dimensions are 3.302cm in length, 11.43cm in width, and 13.462cm in height, making it a convenient size for everyday use.
Abreva's model number is 2216364, which guarantees that you are purchasing the authentic product. This powerful formula works quickly to relieve pain and reduce the appearance of cold sores. Abreva is a must-have for anyone who wants to heal cold sores quickly and effectively.
This product is perfect for busy individuals who need a fast-acting solution. It is also ideal for people who want to maintain a healthy and attractive appearance during cold sore outbreaks. Abreva is an essential part of any cold sore treatment regimen and is recommended by healthcare professionals worldwide.
10. Severe Cold Relief Honey Lemon Powder Packets

The Theraflu Multi-Symptom Severe Cold Medicine Powder Packets are a powerful and effective solution to relieve cold symptoms such as sore throat pain, headache, minor body aches and pains, nasal and sinus congestion, cough, and fever. Each package contains 6 powder packets infused with green tea and honey lemon flavors that make it a delicious and easy-to-take solution for cold, cough, and sore throat relief.
The Theraflu powder packets are formulated to dissolve quickly in hot water, making it as easy as making a cup of tea. Each packet contains dextromethorphan HBr 20 mg, acetaminophen 500 mg, and phenylephrine HCl 10 mg, which are known to provide multi-symptom relief from cold and cough.
To use Theraflu powder packets, simply dissolve one packet in 8 ounces of hot water and enjoy the delicious green tea and honey lemon-infused flavors. Adults and children aged 12 and older can take it every four hours as needed for symptom relief.
Best Otc Medicine For Cold Sores FAQs
Are there any natural remedies that can be used in place of OTC cold sore medicines?
Yes, there are several natural remedies that can be used as an alternative to over-the-counter cold sore medicines. Some of these remedies include:
1. Tea tree oil: This essential oil has antiviral properties and can be applied topically to help speed up the healing process.
2. Aloe vera: The gel from the aloe vera plant can be applied directly to cold sores to help soothe the skin and reduce inflammation.
3. Lemon balm: This herb has antiviral properties and can be applied topically as a cream or ointment to help relieve cold sore symptoms.
4. Echinacea: This herb can help boost the immune system and may help prevent cold sores from forming.
5. Lysine: This amino acid has been shown to help reduce the frequency and severity of cold sore outbreaks.
It's important to note that natural remedies may not work for everyone, and it's always a good idea to consult with a healthcare provider before trying any new treatment. Additionally, while natural remedies may be effective in reducing symptoms, they may not be as powerful as prescription medications in treating cold sores.
Are there any side effects associated with OTC cold sore medicines?
There can be some side effects associated with over-the-counter (OTC) cold sore medicines, but they are generally considered safe when used as directed. The most common side effects are mild burning or stinging at the site of application. Some people may also experience dryness or flakiness of the skin.
It's important to use OTC cold sore medicines exactly as directed on the packaging. Overuse can cause more serious side effects, such as skin irritation or allergic reactions. If you experience any severe side effects or an allergic reaction, stop using the product immediately and seek medical attention.
It's also important to note that OTC cold sore medicines may not be effective for everyone. If you have frequent or severe cold sores, it's best to consult with a healthcare provider for personalized treatment options.
Overall, OTC cold sore medicines are generally safe and effective when used as directed, but it's important to be aware of potential side effects and to use them appropriately.
Are there any specific brands of OTC cold sore medicines that are particularly effective?
There are several over-the-counter (OTC) cold sore medicines available in the market, but not all of them are equally effective. However, some of the most popular and effective OTC cold sore medicines include Abreva, Zovirax, and Compeed.
Abreva is an FDA-approved cream that contains docosanol, which works by blocking the virus's ability to replicate and spread. It is a popular choice among consumers due to its ability to shorten the healing time of cold sores. Zovirax contains acyclovir, which helps to reduce the duration and severity of symptoms. It is available in cream and ointment form and can be applied directly to the affected area. Compeed is a cold sore patch that contains hydrocolloid technology, which helps to reduce symptoms like pain and itching while also promoting healing.
It's important to note that not all cold sores are the same, and what works for one person may not work for another. It is advisable to consult with a healthcare professional before using any OTC cold sore medicine, especially if you have any underlying health conditions or are taking any medications.
Can OTC cold sore medicines be used in conjunction with prescription medications?
It is always recommended to consult with a healthcare provider before combining any medications, including over-the-counter (OTC) cold sore medicines and prescription medications. Although OTC cold sore medicines are generally safe to use, there may be potential interactions with certain prescription medications. For example, if you are taking an antiviral medication for herpes, using an OTC cold sore medicine may not be necessary and could potentially cause unwanted side effects. Additionally, some prescription medications can weaken the immune system, which could make cold sores worse or more difficult to treat. Your healthcare provider can provide guidance on the best course of treatment for your specific situation and help you avoid any potential interactions or negative effects. Always be sure to follow the instructions on the packaging of any medication and never exceed the recommended dosage without medical advice.
Can OTC medicines help prevent cold sores?
Over-the-counter (OTC) medicines can help prevent cold sores to a certain extent. Cold sores are caused by the herpes simplex virus and are highly contagious. OTC medications that are commonly used to prevent cold sores include antiviral creams, ointments, and lip balms that contain docosanol, acyclovir, or penciclovir. These medications work by inhibiting the virus from replicating and spreading.
In addition to using OTC medications, there are several lifestyle changes that can help prevent cold sores. This includes avoiding triggers such as stress, sun exposure, and certain foods, maintaining good hygiene, and avoiding close contact with those who have an active outbreak.
However, it is important to note that OTC medications and lifestyle changes may not always prevent cold sores from occurring. If you experience frequent or severe outbreaks, it is recommended to seek medical advice from a healthcare professional who may prescribe antiviral medications or other treatments to manage the symptoms.
How often should OTC cold sore medicines be applied?
Over-the-counter (OTC) cold sore medicines are usually available in the form of creams, gels, or ointments. These medicines are designed to help relieve the symptoms of cold sores, such as pain, itching, and burning. The frequency of application of OTC cold sore medicines depends on the specific product being used.
In general, most OTC cold sore medicines should be applied at least 4 to 5 times a day, or as directed by a healthcare professional. It is important to follow the instructions on the product label carefully and not to exceed the recommended dosage or frequency of application.
Some OTC cold sore medicines may also come with specific applicators or instructions for use. For example, some products may require you to use a cotton swab or a clean finger to apply a small amount of the medicine directly to the cold sore. Others may come with a special applicator that can help you apply the medicine more precisely.
It is important to note that while OTC cold sore medicines can help relieve the symptoms of cold sores, they are not a cure for the underlying virus that causes cold sores. Therefore, it is important to continue to practice good hygiene and avoid close contact with others while you have a cold sore to prevent spreading the virus.
How quickly do OTC cold sore medicines work?
Over-the-counter (OTC) cold sore medicines are designed to provide quick relief from the symptoms of cold sores, such as pain, itching, and burning. The effectiveness of these medicines can vary depending on the specific product and the severity of the cold sore.
Some OTC cold sore medicines contain antiviral ingredients, such as acyclovir or docosanol, which work to reduce the duration and severity of cold sores. These products can start to work within a few hours of application and may continue to provide relief for several days.
Other OTC cold sore medicines contain pain relievers and numbing agents, such as benzocaine or lidocaine, which provide temporary relief from cold sore symptoms. These products may start to work within minutes of application and can provide relief for several hours.
It is important to read and follow the instructions on the product packaging to ensure that the medicine is used correctly and effectively. If the cold sore does not improve or worsens after a few days of using OTC medicines, it is recommended to consult a healthcare professional for further evaluation and treatment.
What are the active ingredients in the best OTC medicine for cold sores?
The best OTC medicine for cold sores typically contains active ingredients like docosanol, benzocaine, and lidocaine. Docosanol is an antiviral agent that can help reduce the duration of cold sore outbreaks. It works by preventing the herpes simplex virus from entering healthy cells and replicating. Benzocaine and lidocaine are local anesthetics that help relieve pain and discomfort associated with cold sores. They work by numbing the affected area and reducing itching and burning sensations. Other common ingredients found in OTC cold sore medicines include menthol, camphor, and phenol, which can also provide temporary relief from symptoms. It's important to carefully read and follow the instructions on the packaging and consult with a healthcare provider if symptoms persist or worsen. It's also important to note that OTC cold sore medicines are not a cure for the herpes simplex virus and will not prevent future outbreaks.
What are the most effective over-the-counter medicines for cold sores?
Cold sores, also known as fever blisters, are caused by the herpes simplex virus and can be both uncomfortable and unsightly. Fortunately, there are several over-the-counter medicines that can help manage symptoms and speed up healing.
One of the most effective OTC medicines for cold sores is docosanol, which is available under the brand name Abreva. This cream works by blocking the virus from entering healthy cells and can reduce healing time by up to two days.
Another option is to use a topical antiviral cream containing acyclovir or penciclovir. These creams can help reduce the severity and duration of symptoms, but they work best when applied at the first sign of a cold sore.
In addition to creams, there are also OTC medications that contain pain relievers like benzocaine or lidocaine. These can help reduce discomfort and itching associated with cold sores.
It is important to remember that while these medications can help manage symptoms, they cannot cure the herpes simplex virus. If you experience frequent or severe cold sores, it is best to speak with a healthcare professional for personalized treatment options.
What is the recommended dosage for OTC cold sore medicines?
The recommended dosage for over-the-counter (OTC) cold sore medicines may vary depending on the specific medication and its active ingredients. It is important to carefully read and follow the instructions on the packaging or consult with a healthcare professional for guidance.
Generally, most OTC cold sore medicines contain antiviral ingredients such as acyclovir, docosanol, or benzyl alcohol. Acyclovir creams or ointments are typically applied to the affected area five times a day for up to ten days. Docosanol creams are applied to the cold sore at the first sign of symptoms and up to five times a day thereafter until the sore has healed. Benzyl alcohol is applied every two hours while awake for four days.
It is important to note that OTC cold sore medicines are not a cure for the herpes simplex virus that causes cold sores, but they can help to alleviate symptoms and speed up healing time. If symptoms persist or worsen, it is recommended to seek medical advice.