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20 Best Oral Flea And Tick Prevention For Dogs (2022 Updated)

The most common oral flea and tick prevention for dogs is Trifexis. This oral medication is a monthly pill that not only prevents fleas and ticks, but also heartworm disease.

20 Best Oral Flea And Tick Prevention For Dogs

Product Image Product Name Features Price

Only Natural Pet EasyDefense Barrier Bites Soft Chews (90 Soft Chews)

  • Flea & tick prevention supplement in a tasty, bacon-flavored soft chew.
  • Completely safe as a supplement for everyday use – contains no harmful chemicals.

Nexgard Chewable Tablets for Dogs 24.1 – 60.0 lbs, Size: 1 Count | PetSmart

  • 1 Count

Capstar Flea Tablets for Dogs Over – 2-25 lbs – 6 ct

  • 6 Ct

Capstar Flea Tablets for Dogs, Over 25 lbs, 6-Count

  • Over 25 lbs

Frontline Plus Flea & Tick for Dogs, Up to 22 lbs, 3 Doses

  • 11-22 lbs

Nexgard Chewable Tablets for Dogs, 4-10 lbs

  • Possible side effects.
  • If you miss giving a dose, give it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Do not double the dose.

Capstar Flea Tablets for Dogs and Cats

  • Kills fleas fast and effectively!
  • Easy to administer by simply hiding in food.
  • If your pet becomes re-infested, another dose can be given the following day and once per day following that.

Capstar 11.4mg 6 Tablets

  • Manage one tablet a day when you detect that your dog has fleas.
  • Repeat the treatment whenever you see fleas on your dogand cat.

VetIQ Flea Guard 90 Tablets

  • Round Tablet

Simparica Trio Chewable Tablets 44.1-88 lbs 1 Dose

  • (44.1-88 lbs), 6

Comfortis Chewable Tablets for Dogs & Cats, 140 mg – 6 count

  • Comfortis comes in a convenient, beef-flavored chewable
  • Starts to kill fleas within 30 minutes and protection lasts an entire month

Nexgard for Dogs 24.1 – 60.0 lbs,3 Month Supply

  • 24.1-60 lbs

Simparica 40mg Chewable Tablets for Dogs >10-20 kg (22-44 lbs)

  • Simparica is an easy to eat monthly chewable tablet that fights away fleas, tick, mites and mange.
  • The benefits of Simparica include Kills fleas within 3 hours with a complete kill in 8 hours after treatment.

Simparica Chewable Tablets for Dogs- 6 Dose- 44.1-88lb

  • 44.1-88.0 lbs

Credelio for Dogs: Orange (12.1-25lbs), 1 Tablet

  • 1 Ct

Bravecto 1-Month Chews Small Dog (9.9-22 lbs) 1 Pk

  • 9.9-22 lbs

Trifexis Chewable Tablets for Dogs, Blue – 6 count

  • 40.1-60 lbs

Sentinel Spectrum for Dogs – 50-100 lbs – 6 Count

  • 50-100 lbs

Bravecto for Dogs 44-88 lbs 1 Tablet

  • 44-88 lbs
Only Natural Pet EasyDefense Barrier Bites Soft Chews (90 Soft Chews)
  • Flea & tick prevention supplement in a tasty, bacon-flavored soft chew.
  • Completely safe as a supplement for everyday use – contains no harmful chemicals.
Nexgard Chewable Tablets for Dogs 24.1 – 60.0 lbs, Size: 1 Count | PetSmart
  • 1 Count
Capstar Flea Tablets for Dogs Over – 2-25 lbs – 6 ct
  • 6 Ct
Capstar Flea Tablets for Dogs, Over 25 lbs, 6-Count
  • Over 25 lbs
Frontline Plus Flea & Tick for Dogs, Up to 22 lbs, 3 Doses
  • 11-22 lbs
Nexgard Chewable Tablets for Dogs, 4-10 lbs
  • Possible side effects.
  • If you miss giving a dose, give it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Do not double the dose.
Capstar Flea Tablets for Dogs and Cats
  • Kills fleas fast and effectively!
  • Easy to administer by simply hiding in food.
  • If your pet becomes re-infested, another dose can be given the following day and once per day following that.
Capstar 11.4mg 6 Tablets
  • Manage one tablet a day when you detect that your dog has fleas.
  • Repeat the treatment whenever you see fleas on your dogand cat.
VetIQ Flea Guard 90 Tablets
  • Round Tablet
Simparica Trio Chewable Tablets 44.1-88 lbs 1 Dose
  • (44.1-88 lbs), 6
Comfortis Chewable Tablets for Dogs & Cats, 140 mg – 6 count
  • Comfortis comes in a convenient, beef-flavored chewable
  • Starts to kill fleas within 30 minutes and protection lasts an entire month
Nexgard for Dogs 24.1 – 60.0 lbs,3 Month Supply
  • 24.1-60 lbs
Simparica 40mg Chewable Tablets for Dogs >10-20 kg (22-44 lbs)
  • Simparica is an easy to eat monthly chewable tablet that fights away fleas, tick, mites and mange.
  • The benefits of Simparica include Kills fleas within 3 hours with a complete kill in 8 hours after treatment.
Simparica Chewable Tablets for Dogs- 6 Dose- 44.1-88lb
  • 44.1-88.0 lbs
Credelio for Dogs: Orange (12.1-25lbs), 1 Tablet
  • 1 Ct
Bravecto 1-Month Chews Small Dog (9.9-22 lbs) 1 Pk
  • 9.9-22 lbs
Trifexis Chewable Tablets for Dogs, Blue – 6 count
  • 40.1-60 lbs
Sentinel Spectrum for Dogs – 50-100 lbs – 6 Count
  • 50-100 lbs
Bravecto for Dogs 44-88 lbs 1 Tablet
  • 44-88 lbs

1. Only Natural Pet EasyDefense Barrier Bites Soft Chews (90 Soft Chews)

Only Natural Pet EasyDefense Barrier Bites Soft Chews (90 Soft Chews)

  • Flea & tick prevention supplement in a tasty, bacon-flavored soft chew.
  • Completely safe as a supplement for everyday use – contains no harmful chemicals.
  • Formulated with proven ingredients like garlic, brewer’s yeast, and complex b-vitamins.
  • Works to maintain your pet’s healthy skin & coat by maintaining proper skin and tissue function.
  • Only Natural Pet brand products are 100% Guaranteed!

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PetSmart

Product Details

Specifications

Details
Package Dimensions 4.13 x 3.7 x 3.66 inches; 11.11 Ounces
Item Package Dimensions L x W x H 4.13 x 3.7 x 3.66 inches
Target Audience Keyword Dogs

2. Nexgard Chewable Tablets for Dogs 24.1 – 60.0 lbs, Size: 1 Count | PetSmart

Nexgard Chewable Tablets for Dogs 24.1 - 60.0 lbs, Size: 1 Count | PetSmart

  • 1 Count

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Amazon
Allivet Pet Pharmacy
Chewy.com
EntirelyPets Pharmacy

Product Details

Reviews From Real Customers

Julie L
Lynn M
Carolyn L

3. Capstar Flea Tablets for Dogs Over – 2-25 lbs – 6 ct

Capstar Flea Tablets for Dogs Over - 2-25 lbs - 6 ct

  • 6 Ct

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Walmart
PetSmart

Product Details

Specifications

Details
Active Ingredients Nitenpyram
Animal Type Dog
Breed Size Small
Effective Time Period 24 hours
Manufacturer Brand Capstar

Reviews From Real Customers

simon7sez
johnjaye1
RGpets29

4. Capstar Flea Tablets for Dogs, Over 25 lbs, 6-Count

Capstar Flea Tablets for Dogs, Over 25 lbs, 6-Count

  • Over 25 lbs

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Amazon
Tractor Supply Company
Petco.com
VetRxDirect a Pet Pharmacy

Product Details

Specifications

Details
Active Ingredients Nitenpyram
Animal Type Dog
Breed Size Medium, Large
Effective Time Period 24 hours
Manufacturer Brand Capstar

5. Frontline Plus Flea & Tick for Dogs, Up to 22 lbs, 3 Doses

Frontline Plus Flea & Tick for Dogs, Up to 22 lbs, 3 Doses

  • 11-22 lbs

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Amazon
Walmart
Petco.com
SPC Pets

Product Details

Specifications

Details
Units in Package 3
Unit Size 0.023 fl oz applicators
Directions It is a violation of Federal Law to use this product in a manner inconsistent with its labeling. Do not allow children to apply product. To prevent harm to you and your pet read entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully use on dogs only. Do not use on rabbits. Do not use on other animals. To kill fleas, all stages of brown dog ticks, American dog ticks, lone star ticks, and deer ticks (which may carry Lyme disease) and chewing lice, apply to dogs or puppies (8 weeks or older) as follows: Remove applicator from child-resistant package. Hold applicator upright and snap applicator tip away from face and body. Place applicator tip through animal’s hair to the skin level between the shoulder blades. Squeeze applicator, applying entire contents in a single spot to the animal’s skin. Avoid superficial application to the animal’s hair. Only one applicator per treatment is needed. Frontline Plus aids in the control of sarcoptic mange infestations. Multiple monthly treatments are recommended for the elimination of mites. Frontline Plus for Dogs can also be used for the treatment and control of flea, tick and chewing lice infestations on breeding, pregnant and lactating bitches. Frequency of Application: When used monthly, Frontline Plus for Dogs completely breaks the flea life cycle and controls tick and chewing lice infestations. Research demonstrates that Frontline Plus kills adult fleas, flea eggs, and flea larvae for up to three months. Frontline Plus also prevents development of all flea stages for up to three months. Although Frontline Plus can control fleas for up to three months, if there is a high risk of reinfestation or if the pet has fleas which may cause flea allergy dermatitis, a once monthly application may be needed. Frontline Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. Frontline Plus kills chewing lice for at least one month. A once monthly application is recommended where chewing lice control is needed. For animal use only.
Ingredients Active Ingredients: Fipronil (9.8%), (S)-Methoprene (8.8%), Inert Ingredients: (81.4%).
Warnings Keep out of reach of children.

Reviews From Real Customers

JCar
MeOrTheDog
Kagman

6. Nexgard Chewable Tablets for Dogs, 4-10 lbs

Nexgard Chewable Tablets for Dogs, 4-10 lbs

  • Possible side effects.
  • If you miss giving a dose, give it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Do not double the dose.

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Amazon
Allivet Pet Pharmacy
Spring Meds

Product Details

Reviews From Real Customers

Melanie Wasinger
Settles Fur Babies
Littedar K

7. Capstar Flea Tablets for Dogs and Cats

Capstar Flea Tablets for Dogs and Cats

  • Kills fleas fast and effectively!
  • Easy to administer by simply hiding in food.
  • If your pet becomes re-infested, another dose can be given the following day and once per day following that.
  • This product is totally safe for dogs, cats, puppies and kittens 2 pounds or more and 4 weeks or older.
  • It is even safe for breastfeeding or pregnant dogs and cats.

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eBay – buy_great_deals
Sears
petocart.com

Product Details

Specifications

Details
Form Pills

Reviews From Real Customers

cathy.c
JF501
brandy.f

8. Capstar 11.4mg 6 Tablets

Capstar 11.4mg 6 Tablets

  • Manage one tablet a day when you detect that your dog has fleas.
  • Repeat the treatment whenever you see fleas on your dogand cat.
  • Can be administered in pregnant and / or lactating females.

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Amazon
Vivapets

Product Details

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Nasreen A
melwo_4203
tarielm09_7

9. PetArmor CapAction Flea Tabs for Dogs 25+ Pounds – Each

PetArmor CapAction Flea Tabs for Dogs 25+ Pounds - Each

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Sam’s Club

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Specifications

Details
Assembled Product Weight 0.098 oz

Reviews From Real Customers

DwayneM
Amcinti
corvette guy

10. VetIQ Flea Guard 90 Tablets

VetIQ Flea Guard 90 Tablets

  • Round Tablet

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eBay

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Details
Product Genre/Category Pet Products

Reviews From Real Customers

chick-pea-daal
tan229
aljama445

11. Simparica Trio Chewable Tablets 44.1-88 lbs 1 Dose

Simparica Trio Chewable Tablets 44.1-88 lbs 1 Dose

  • (44.1-88 lbs), 6

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Valley Vet Supply
PetMeds
VetRxDirect a Pet Pharmacy
petvm.com

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DaisysMom
LexYve93
Boo Ba Loo

12. Comfortis Chewable Tablets for Dogs & Cats, 140 mg – 6 count

Comfortis Chewable Tablets for Dogs & Cats, 140 mg - 6 count

  • Comfortis comes in a convenient, beef-flavored chewable
  • Starts to kill fleas within 30 minutes and protection lasts an entire month
  • Spinosad, the active ingredient in Comfortis, is environmentally friendly

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Vet Approved RX

Product Details

Specifications

Details
Primary Brand Comfortis
For Pet Weight Max 10 LBS
For Pet Weight Min 4.1 LBS

Reviews From Real Customers

Gingi

13. Nexgard for Dogs 24.1 – 60.0 lbs,3 Month Supply

Nexgard for Dogs 24.1 - 60.0 lbs,3 Month Supply

  • 24.1-60 lbs

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Allivet Pet Pharmacy
FarmVet.com
Heartland Veterinary Supply and Pharmacy
California Pet Pharmacy

Product Details

14. Simparica 40mg Chewable Tablets for Dogs >10-20 kg (22-44 lbs)

Simparica 40mg Chewable Tablets for Dogs data-lazy-src=

Simparica Chewables are flavoured tablets specifically designed for dogs for their monthly flea and tick protection. The oral tablets start working quickly and remain strong for 35 days without losing its effectiveness.

The fast acting formula starts killing fleas within 3 hours and ticks within 8 hours. When given on regular interval of one month, Simparica offers persistent protection from fleas and ticks.

Reviews From Real Customers

Judy Perryman
Tara m
m-marfa-sweoxis

15. Simparica Chewable Tablets for Dogs- 6 Dose- 44.1-88lb

Simparica Chewable Tablets for Dogs- 6 Dose- 44.1-88lb

  • 44.1-88.0 lbs

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Chewy.com
Allivet Pet Pharmacy
Valley Vet Supply
PetMeds

Product Details

Specifications

Details
For Use With Dogs
Administration Form Oral
Breed Size Medium Breeds, Large Breeds
Product Form Chewable Tablet
Strength 80 mg Sarolaner

Reviews From Real Customers

soraya.h
The Pup Mommy
Cherry123

16. Credelio for Dogs: Orange (12.1-25lbs), 1 Tablet

Credelio for Dogs: Orange (12.1-25lbs), 1 Tablet

  • 1 Ct

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Walmart – Walmart Pet RX
Koala Health

Product Details

Specifications

Details
For Use With Dogs – 8 weeks or older
Administration Form Oral
Breed Size Small Breeds
Product Form Chewable Tablet
Strength 225 mg Lotilaner

Reviews From Real Customers

Lozard
Charity W
JenW

17. Bravecto 1-Month Chews Small Dog (9.9-22 lbs) 1 Pk

Bravecto 1-Month Chews Small Dog (9.9-22 lbs) 1 Pk

  • 9.9-22 lbs

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Chewy.com
Allivet Pet Pharmacy
Valley Vet Supply
PetMeds

Product Details

Specifications

Details
Administration Form Oral
For Use With Dogs
Breed Size Large Breeds, Small Breeds, Medium Breeds
Product Form Chew
Strength 100 mg fluralaner

Reviews From Real Customers

TKT1964
Hefty
Bumble

18. Trifexis Chewable Tablets for Dogs, Blue – 6 count

Trifexis Chewable Tablets for Dogs, Blue - 6 count

  • 40.1-60 lbs

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Petco.com
EntirelyPets Pharmacy
Chewy.com

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lacy.s
A veteran

19. Sentinel Spectrum for Dogs – 50-100 lbs – 6 Count

Sentinel Spectrum for Dogs - 50-100 lbs - 6 Count

  • 50-100 lbs

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Chewy.com
petvm.com
Revival Animal Health
EntirelyPets Pharmacy

Product Details

Specifications

Details
For Use With Dogs
Administration Form Oral
Breed Size Medium Breeds, Large Breeds
Product Form Chew
Drug Type Parasiticide

Reviews From Real Customers

nikki.j
mic.v
YeCats

20. Bravecto for Dogs 44-88 lbs 1 Tablet

Bravecto for Dogs 44-88 lbs 1 Tablet

  • 44-88 lbs

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Walmart – Walmart Pet RX
Allivet Pet Pharmacy
PetCareRx
VetRxDirect a Pet Pharmacy

Product Details

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Details
Primary Brand Bravecto

Reviews From Real Customers

Roxabox
Ozzy
RamintaIV

Conclusion

Some factors that could influence the conclusion of oral flea and tick prevention for dogs include the efficacy of the product, the pet’s individual reaction to the product, the pet’s lifestyle and environment, and the owner’s personal preference.

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