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20 Best Flea Medicine For Dogs And Cats (2022 Updated)

The most common type of flea medicine for dogs and cats is a topical medication that is applied to the skin. This type of medication is typically effective for about four weeks. Some of the active ingredients in these medications include imidacloprid, fipronil, and pyriproxyfen.

20 Best Flea Medicine For Dogs And Cats

1. Advantage II Flea Treatment for Kittens, 2 Doses

Advantage II Flea Treatment for Kittens, 2 Doses

  • 4.25 x 1 x 4.75 inches; 0.48 Ounces

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Weight 1.28 oz

2. Vet’s Best Flea and Tick Wipes 50 Count

Vet's Best Flea and Tick Wipes 50 Count

  • Kills fleas, flea eggs, and ticks by contact while repelling mosquitos.
  • Portable wipes are easy and convenient to use for a targeted application.
  • A great way to protect dogs and cats 12 weeks and older.
  • Absolutely no pyrethrins, permethrins, or cedar oil.
  • Non-staining formula that is great for home surfaces like countertops and flooring.

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The Cheshire Horse
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PetGuys

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Is Discontinued By Manufacturer No
Product Dimensions 3.3 x 8 x 3.3 inches; 0.16 Ounces
Country of Origin USA
Item Package Dimensions L x W x H 7.76 x 3.35 x 3.03 inches
Item Dimensions LxWxH 3.3 x 8 x 3.3 inches

3. Frontline Plus Flea, Tick & Lice Killer, for Cats – 3 doses

Frontline Plus Flea, Tick & Lice Killer, for Cats - 3 doses

  • Kills all existing fleas on your pet within 18 hours
  • Each application provides a full month of protection
  • Also aids in the control of sarcoptic mange infections
  • Great for pets that swim since it’s waterproof

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Units in Package 3
Directions See insert for first aid and precautionary statements. It is a violation of Federal Law to use this product in a manner inconsistent with its labeling. Do not allow children to apply product. To prevent harm to you and your pet, read entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully. Use on cats only. Do not use on rabbits. Do not use on other animals. To kill fleas, flea eggs & larvae, ticks, and chewing lice apply Frontline Plus for Cats as follows: To Remove Applicator: Lift and remove the plastic tab to expose foil backing; then peel away the foil. Or use scissors to open. Open applicator. Hold upright with foil side toward you and snap applicator tip. Apply Frontline Plus. Part the cat’s hair above the shoulder blades, at the base of the neck. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the cat’s skin. Do not apply on top of the hair coat. Avoid contact with treated area until dry. Frontline Plus for Cats is approved for use on all cats, including breeding, pregnant, and lactating queens and kittens as young as 8 weeks. Frontline Plus remains effective even after bathing, water immersion, or exposure to sunlight. Frequency of Application: When used monthly, Frontline Plus completely breaks the flea life cycle and controls tick and chewing lice infestations. Do not reapply Frontline Plus for 30 days. Frontline Plus kills adult fleas, flea eggs, and flea larvae for up to six weeks. Frontline Plus also prevents development of all flea stages for up to six weeks. Frontline Plus can control fleas for up to six weeks, however, if there is a high risk of reinfestation or if the cat has fleas which may cause flea allergy dermatitis, a once monthly application may be needed. Frontline Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. Frontline Plus kills all life stages of ticks (larva, nymph and adult). Frontline Plus kills ticks that may transmit Lyme disease, Rocky Mountain spotted fever, ehrlichiosis, babesiosis, anaplasmosis, haemobartonellosis and other tick-borne diseases. Frontline Plus kills chewing lice for at least one month. A once monthly application is recommended where chewing lice control is needed.
Ingredients Active Ingredients: Fipronil (9.8%), (S)-Methoprene (11.8%). Inert Ingredients: (78.4%).
Warnings Keep out of reach of children.

4. Frontline Plus Flea, Tick & Lice Killer, for Dogs – 3 doses

Frontline Plus Flea, Tick & Lice Killer, for Dogs - 3 doses

  • Stops flea infestation
  • Kills adult fleas ticks flea eggs and larvae
  • Prevents all flea stages (eggs larvae pupae) from developing
  • Kills ticks that may transmit diseases
  • Provides waterproof effectiveness

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Units in Package 3
Directions See insert for first aid and precautionary statements. It is a violation of Federal Law to use this product in a manner inconsistent with its labeling. Do not allow children to apply product. To prevent harm to you and your pet, read entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully. Use on dogs only. Do not use on rabbits. Do not use on other animals. To kill fleas, flea eggs & larvae, ticks, and chewing lice apply Frontline Plus for Dogs as follows: To Remove Applicator: Lift and remove the plastic tab to expose foil backing; then peel away the foil. Or use scissors to open. Open applicator. Hold upright with foil side toward you and snap applicator tip. Apply Frontline Plus. Part the dog’s hair between the shoulder blades. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the animal’s skin. Do not apply on top of the hair coat. Avoid contact with treated area until dry. Frontline Plus is approved for use on all dogs, including breeding, pregnant, and lactating bitches and puppies as young as 8 weeks. Frontline Plus remains effective even after bathing, water immersion, or exposure to sunlight. Frequency of Application: When used monthly, Frontline Plus completely breaks the flea life cycle and controls tick and chewing lice infestations. Do not reapply Frontline Plus for 30 days. Frontline Plus kills adult fleas, flea eggs, and flea larvae for up to three months. Frontline Plus also prevents development of all flea stages for up to three months. Frontline Plus can control fleas for up to three months, however, if there is a high risk of reinfestation or if the pet has fleas which may cause flea allergy dermatitis, a once monthly application may be needed. Frontline Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. Frontline Plus kills all life stages of ticks (larva, nymph and adult). Frontline Plus kills ticks that may transmit Lyme disease, Rocky Mountain spotted fever, ehrlichiosis, babesiosis, anaplasmosis and other tick-borne diseases. Frontline Plus kills chewing lice for at least one month. A once monthly application is recommended where chewing lice control is needed. Frontline Plus aids in the control of sarcoptic mange infestations. Multiple monthly treatments are recommended for the elimination of mites.
Ingredients Active Ingredients: Fipronil (9.8%), (S)-Methoprene (8.8%). Inert Ingredients: (81.4%).
Warnings Keep out of reach of children.

5. Capstar Flea Tablets for Cats 2-25 lbs, 6 Count

Capstar Flea Tablets for Cats 2-25 lbs, 6 Count

  • Pack Of 6

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6. Capstar Flea Tablets for Dogs, Over 25 lbs, 6-Count

Capstar Flea Tablets for Dogs, Over 25 lbs, 6-Count

  • Over 25 lbs

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Active Ingredients Nitenpyram
Animal Type Dog
Breed Size Medium, Large
Effective Time Period 24 hours
Manufacturer Brand Capstar

7. Adams Plus Flea and Tick Dip with Pyrethrin 4 oz.

Adams Plus Flea and Tick Dip with Pyrethrin 4 oz.

  • 4 oz

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Walmart – Piccard meds 4 pets Corp
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Jefferspet.com

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Is Discontinued By Manufacturer No
Product Dimensions 1.65 x 1.65 x 5.1 inches; 4.48 Ounces
Country of Origin USA
Item Package Dimensions L x W x H 4.92 x 2.05 x 1.93 inches
Item Dimensions LxWxH 1.65 x 1.65 x 5.1 inches

8. Capstar Flea Tablets for Dogs and Cats

Capstar Flea Tablets for Dogs and Cats

  • Kills fleas fast and effectively!
  • Easy to administer by simply hiding in food.
  • If your pet becomes re-infested, another dose can be given the following day and once per day following that.
  • This product is totally safe for dogs, cats, puppies and kittens 2 pounds or more and 4 weeks or older.
  • It is even safe for breastfeeding or pregnant dogs and cats.

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Form Pills

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Nasreen A

9. Advantage II Flea Treatment for Large Cats Over 9 lbs 6 Pack

Advantage II Flea Treatment for Large Cats Over 9 lbs 6 Pack

  • Key Benefits.
  • Veterinarian-recommended treatment kills all life stages of fleas on kittens and cats 8 weeks or older and weighing over 9 pounds.
  • Begins working within 12 hours to kill fleas on contact.
  • Kills eggs, larvae and adult fleas to break the life-cycle and help prevent re-infestation.
  • Waterproof formula continues working for up to four weeks, even after bathing.

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Weight 4.64 oz

10. Advantage II for Dogs Over 55 lbs 6 Pack

Advantage II for Dogs Over 55 lbs 6 Pack

  • Over 55 lbs

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Medi-Vet Animal Health

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Active Ingredient % By Weight
Imidacloprid 9.10%
Pyriproxyfen 0.46%
Other Ingredients 90.44%

11. CapAction Oral Flea Treatment for Cats Under 25lbs.

CapAction Oral Flea Treatment for Cats Under 25lbs.

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Revival Animal Health

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Assembled Product Weight 0.05 lb
Animal Type Cat
Assembled Product Dimensions (L x W x H) 0.57 x 4.57 x 2.75 Inches

12. Capstar Flea Tablets for Dogs & Cats, Blue (2-25 lbs) – 6 pack, 11.4 mg tablets

Capstar Flea Tablets for Dogs & Cats, Blue (2-25 lbs) - 6 pack, 11.4 mg tablets

  • Capstar Flea Pills provide fast-acting, effective pest control
  • Treats flea infestations on dogs, puppies, cats and kittens four weeks of age and older and two pounds of body weight or greater
  • Capstar for fleas also works for pregnant or nursing dogs and cats
  • Fast acting formula begins working within 30 minutes
  • Guaranteed to kill almost all adult fleas within four hours of ingestion

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Primary Brand Capstar
For Pet Weight Max 25 LBS
For Pet Weight Min 2 LBS

13. CrossBlock II Flea Treatment for Dogs & Cats (crossblock: Cat Over 9lbs)

CrossBlock II Flea Treatment for Dogs & Cats (crossblock: Cat Over 9lbs)

  • Kills adult fleas and prevents further re-infestation on dogs
  • Kills re-infestation fleas within 2 hours
  • Breaks the flea life cycle and prevents flea eggs and larvae from developing into adult fleas
  • Waterproof after application
  • Effective for one month

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14. PetLock II Topical Flea Treatment for Medium Dogs 11-20 Pounds 4 Doses

PetLock II Topical Flea Treatment for Medium Dogs 11-20 Pounds 4 Doses

  • Contains the same active ingredients used in Bayer Advantage II.
  • Kills and controls all flea life stages (flea eggs, flea larvae, and adult fleas).
  • Waterproof and fragrance free formula.
  • PetLock II is a once-a-month topical flea treatment for dogs 7 weeks of age or older. PetLock II kills and controls all flea life stages.

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Gibson’s Natural Pet

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Manufacturer Part Number 818145015298
Product Name II for Dogs
Packaged Quantity 4
Product Type Flea/Tick Control Drop
Animal Type Dog

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15. Tevrapet FirstAct Plus Flea & Ticks Prevention, for Dogs – 3 pack, 0.023 fl oz applicators

Tevrapet FirstAct Plus Flea & Ticks Prevention, for Dogs - 3 pack, 0.023 fl oz applicators

  • 0.023 Fl Oz / 0.02 Fl Oz

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Units in Package 3
Unit Size 0.023 fl oz applicators
Directions Use only on dog and puppies weighing 6-22 lbs. and over 8 weeks or older. Directions for Use: It is a violation of Federal Law to use this product in a manner inconsistent with its labeling. Do not allow children to apply product. To prevent harm to you and your dog, read the entire label and package insert before each use. Follow all directions and precautionary statement carefully use on dogs only. do not use on rabbits or other animals. Restrictions: Do not use on cats, rabbits, or other animals; do not use on puppies under 8 weeks of age and less than 89 lbs.; do not allow your dog to ingest this product; do not apply more frequently than once a day every 4 weeks; do not apply more than one applicator per treatment for one dog regardless of the dog’s weight; do not bathe or allow your dog to swim for 24 hours after application. Frequency of Application: Fleas: When used monthly, Tevrapet First Act Plus for dogs breaks the flea life cycle and controls fleas, flea eggs, and flea larvae on your dog for up to three months. Although Tevrapet First Act Plus for dogs can control fleas up to three months, if there is a high risk of re-infestation of fleas in your dog or if dog has fleas which may cause flea allergy dermatitis apply this product once a month. Ticks: Tervapet First Act Plus for dogs kills larva, nymph and adult ticks that may transmit Lyme disease, Rocky mountain spotted fever, ehrlichiosis, babesiosis, and anaplasmosis for atleast one month. For best control of ticks, apply once every month. Chewing Lice: Tevrapet First Act for dogs kills chewing lice for at least one month. For best control of chewing lice, apply once every month. Sarcoptic Mites: Applied once a month, Tervapet First Act Plus for dogs aids in the control of sarcoptic mite infestations. Do not reapply Tevrapet First act plus for dogs for 30 days. Storage and Disposal: Do not contaminate water, food, or feed by storage or disposal. Storage: Store in a cool, dry place. Protect from freezing. Pesticide Disposal and Container Handling: Nonrefillable container. If empty: Place in trash or offer for recycling if available.
Warnings Caution: See label insert for first aid, precautionary statements and complete directions for use. Keep out of reach of children. Do not use on cats. Side Effects: Monitor your dog after application. Side effects, although very rare, may include signs of skin irritation such as redness, scratching, or other signs of discomfort. Although uncommon, gastrointestinal signs such as vomiting or diarrhea have also been reported. If these or other side effects occur, consult your veterinarian or call 1-800-775-9416. Do not use on cats. Keep cats away from treated dogs for 24 hours. If applied to a cat or ingested by a cat, contact your veterinarian immediately.

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16. K9 Advantix II for Extra Large Dogs Over 55 lbs, 2 Month

K9 Advantix II for Extra Large Dogs Over 55 lbs, 2 Month

  • XL / 2 Dose

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Thomas Dr. Warehouse Florida
Panama City Beach Florida
Destin Florida
Navarre Florida

17. Comfortis Chewable Tablets for Dogs & Cats, 140 mg – 6 count

Comfortis Chewable Tablets for Dogs & Cats, 140 mg - 6 count

  • Comfortis comes in a convenient, beef-flavored chewable
  • Starts to kill fleas within 30 minutes and protection lasts an entire month
  • Spinosad, the active ingredient in Comfortis, is environmentally friendly

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Primary Brand Comfortis
For Pet Weight Max 10 LBS
For Pet Weight Min 4.1 LBS

18. Revolution for Dogs 0-5 lbs 6 Doses by Zoetis

Revolution for Dogs 0-5 lbs 6 Doses by Zoetis

  • Eliminates fleas treatment and prevention
  • Tick Control
  • Dog Flea Tablets

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19. Bob Martin Cat/ Small Dog Flea Tablets 3 Pack

Bob Martin Cat/ Small Dog Flea Tablets 3 Pack

  • Cats & Small Dogs Under 11 kg

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Britishonlinesupermarket.com

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Product Genre/Category Pet Products

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20. Spot on Flea and Tick Treatment for Cats and Dogs – 6 x 1ml Pipettes, Up to 120 Days Protection, Animigo

Spot on Flea and Tick Treatment for Cats and Dogs - 6 x 1ml Pipettes, Up to 120 Days Protection, Animigo

  • without introducing toxic insecticidal substances onto your pets’ skin like the usual flea repellents in the market. Since it’s not a pesticide
  • the pests cannot develop resistance to our spot on formula.EFFECTIVE ‘120-DAYS’ PROTECTION
  • it manages already present fleas or eggs & prevents further infestations as well.TOXICANT-FREE ‘SKIN-SAFE’ FORMULA

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Conclusion

As the best flea medicine for dogs and cats will vary depending on the individual pet’s needs. However, some tips to keep in mind when choosing a flea medicine include considering the pet’s age, weight, health, and lifestyle; making sure the product is safe for both dogs and cats; and selecting a product that is easy to use and administer.

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