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20 Best Flea And Heartworm Prevention For Dogs (2022 Updated)

Flea and heartworm prevention for dogs is a process of protecting dogs from fleas and heartworms. This can be done through various methods such as vaccinations, medications, and natural remedies.

20 Best Flea And Heartworm Prevention For Dogs

Product Image Product Name Features Price

PetArmor Plus Flea, Tick & Lice Treatment, for Dogs & Puppies 4-22 lbs

  • Contains the #1 vet-recommended active ingredient, fipronil and (s)-methoprene, the same active ingredients used in FRONTLINE Plus

Sentinel Flavor Tabs for Dogs – 11-25 lbs – 6 Count

  • Protects your dog against heartworm disease and intestinal worms
  • Easy to administer tablet also helps control fleas
  • Palatable beef-flavored tablets taste like treats

Heartgard Tablets 26-50 lbs, 6 Month Supply

  • 26-50 lbs

Intervet Safe-Guard Canine Dewormer – 3 pack, 1 g packets

  • Mix with food
  • Comes in three day convenient doses
  • Safe and effective

Heartgard Plus for Dogs – 26-50 lbs (1 Chew)

  • 26-50 lbs

Trifexis Chewable Tablets for Dogs 20.1-40 lbs Green, Size: 12 Count | PetSmart

  • 12 Count

Interceptor Rx, 2-10 lbs Dog, Brown, 6 Count

  • 2-10 lbs

Iverhart Plus for Dogs 1-25 lbs, Blue, 6 Pack

  • 1-25 lbs

Interceptor Plus Chewables for Dogs 25.1-50 lbs, 12 Month Supply

  • 25.1-50 lbs

Sentinel Flavor Tabs for Dogs 51-100 lbs, 6 Month Supply

  • White

Iverhart Plus Flavored Chewables for Dogs 51-100 lbs, 6 Month Supply

  • 51-100 lbs, 6 Month

Sentinel Spectrum for Dogs – 8-25 lbs – 6 Count

  • 8-25 lbs

Revolution for Dogs 0-5 lbs 6 Doses by Zoetis

  • Eliminates fleas treatment and prevention
  • Tick Control
  • Dog Flea Tablets

Interceptor Brown, Dogs 2-10 lbs. 12 Month Supply

  • Interceptor is contraindicated in animals with a history of an allergic reaction to milbemycin. Keep out of reach of children.

Sentinel Spectrum 2-8 lbs, 6 Month Supply

  • 2-8 lbs

Simparica Trio Chewable Tablets 44.1-88 lbs 1 Dose

  • (44.1-88 lbs), 6

Heartgard Plus Chewables 1pk Green 26-50lbs for Dogs

  • 26-50 lbs., 1 Month

Tri-Heart Plus for Dogs 26-50 lbs Green 12ct

  • 26-50 lbs
PetArmor Plus Flea, Tick & Lice Treatment, for Dogs & Puppies 4-22 lbs
  • Contains the #1 vet-recommended active ingredient, fipronil and (s)-methoprene, the same active ingredients used in FRONTLINE Plus
Sentinel Flavor Tabs for Dogs – 11-25 lbs – 6 Count
  • Protects your dog against heartworm disease and intestinal worms
  • Easy to administer tablet also helps control fleas
  • Palatable beef-flavored tablets taste like treats
Heartgard Tablets 26-50 lbs, 6 Month Supply
  • 26-50 lbs
Intervet Safe-Guard Canine Dewormer – 3 pack, 1 g packets
  • Mix with food
  • Comes in three day convenient doses
  • Safe and effective
Heartgard Plus for Dogs – 26-50 lbs (1 Chew)
  • 26-50 lbs
Trifexis Chewable Tablets for Dogs 20.1-40 lbs Green, Size: 12 Count | PetSmart
  • 12 Count
Interceptor Rx, 2-10 lbs Dog, Brown, 6 Count
  • 2-10 lbs
Iverhart Plus for Dogs 1-25 lbs, Blue, 6 Pack
  • 1-25 lbs
Interceptor Plus Chewables for Dogs 25.1-50 lbs, 12 Month Supply
  • 25.1-50 lbs
Sentinel Flavor Tabs for Dogs 51-100 lbs, 6 Month Supply
  • White
Iverhart Plus Flavored Chewables for Dogs 51-100 lbs, 6 Month Supply
  • 51-100 lbs, 6 Month
Sentinel Spectrum for Dogs – 8-25 lbs – 6 Count
  • 8-25 lbs
Revolution for Dogs 0-5 lbs 6 Doses by Zoetis
  • Eliminates fleas treatment and prevention
  • Tick Control
  • Dog Flea Tablets
Interceptor Brown, Dogs 2-10 lbs. 12 Month Supply
  • Interceptor is contraindicated in animals with a history of an allergic reaction to milbemycin. Keep out of reach of children.
Sentinel Spectrum 2-8 lbs, 6 Month Supply
  • 2-8 lbs
Simparica Trio Chewable Tablets 44.1-88 lbs 1 Dose
  • (44.1-88 lbs), 6
Heartgard Plus Chewables 1pk Green 26-50lbs for Dogs
  • 26-50 lbs., 1 Month
Tri-Heart Plus for Dogs 26-50 lbs Green 12ct
  • 26-50 lbs

1. PetArmor Plus Flea, Tick & Lice Treatment, for Dogs & Puppies 4-22 lbs

PetArmor Plus Flea, Tick & Lice Treatment, for Dogs & Puppies 4-22 lbs

  • Contains the #1 vet-recommended active ingredient, fipronil and (s)-methoprene, the same active ingredients used in FRONTLINE Plus
  • Kills fleas, flea eggs, flea larvae, ticks and chewing lice for up to 30 days
  • Stops the flea life cycle and kills flea eggs and larvae for up to 12 weeks
  • Kills ticks that may transmit Lyme disease
  • Pet Armor Plus – Waterproof. The item does not have an expiration date

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Product Details

Specifications

Details
Units in Package 3
Unit Size 0.023 fl oz applicators
Directions Read entire label before each use. Use only on dogs and puppies over 8 weeks of age. Directions for Use: It is a violation of Federal law to use this product in a manner inconsistent with its labeling. Do not allow children to apply product. To prevent harm to you and your dog, read entire label before each use. Follow all directions and precautionary statements carefully. Do not use on cats, rabbits or animals other than dogs. Do not allow your dog to ingest this product. Do not use on puppies under 8 weeks of age or less than 4 lbs. Use entire contents of tube on each dog. Do not split one tube between dogs. Do not use multiple tubes on one dog. Weigh your dog to be sure you are applying the right dose formulated for the weight of your dog. Separate the treated dog from all other dogs and cats for 24 hours after treatment has been applied. How to Open: Remove product tubes from the package. Separate one tube from the others. Hold the tube with notched end pointing up and away from the face and body. Use scissors to cut off the narrow end at the notches along the line. How to Apply: Invert tube over dog and use open end to part dog’s hair. Squeeze tube firmly to apply all of the solution to the dog’s skin, as directed below. Do not apply more often than once every 4 weeks. Only for Dogs Weighing 4-22 lbs. Do not apply to dogs weighing less than 4 lbs. Apply one tube (0.023 fl oz)(0.67 ml) as a spot to the dog’s back between the shoulder blades. Frequency of Application: Use this product monthly for complete control of flea, tick, and chewing lice infestations. Studies show that this product kills adult fleas for up to three months. Apply monthly if your dog is at high risk for flea reinfestation. Apply monthly to control ticks and chewing lice. This product remains effective even after bathing, water immersion, or exposure to sunlight. Allow treated area to dry thoroughly. Do not reapply for thirty (30) days. Storage and Disposal: Pesticide Storage: Do not remove tube from the pack until ready to use. Store in a cool (below 77 degrees F/25 degrees C), dry place inaccessible to children and pets. Do not refrigerate. Protect from direct sunlight. Container Disposal: If Empty: Non-refillable container. Do not reuse or refill this container. Offer for recycling if available. If Partly Filled: Call your local solid waste agency for disposal instructions. Never place unused product down any indoor or outdoor drain.
Ingredients Active Ingredients: Fipronil (9.80%), (S)-Methoprene (8.80%), Other Ingredient: (81.40%).
Warnings Do not use on cats. Keep out of reach of children. Caution: See back label for additional precautionary statements. Precautionary Statements: Hazards to humans. Caution. Harmful if swallowed. Causes eye irritation. Avoid contact with skin, eyes or clothing. Wash hands thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco or using the toilet. Hazards to Domestic Animals: For external use on dogs only. Individual sensitivities, while rare, may occur after using any pesticide product on dogs. Certain medications can interact with pesticides. Do not treat your dog with more than one pesticide product at a time. Over dosing your dog can result in serious illness and even death. Consult a veterinarian before using on medicated, debilitated, aged, pregnant or nursing dogs. Consult a veterinarian before using on dogs with known organ dysfunction. If your dog is exhibiting signs of and/or is being treated for skin dermatitis, talk to your veterinarian before applying any topical flea and tick control product. First Aid: If Swallowed: Call a poison control center or a doctor immediately for treatment advice. Have person sip a glass of water if able to swallow. Do not induce vomiting unless told to do so by a poison control center or doctor. Do not give anything by mouth to an unconscious person. If in Eyes: Flush eyes with plenty of water. Call a doctor if irritation persists. If on Skin: Wash with plenty of soap and water. Get medical attention if irritation persists. Hot Line Number: Have the product container or label with you when calling a poison control center or doctor, or going for treatment. You may also contact 1-888-908-Tick (8425) for emergency medical treatment information. Side Effects: Monitor your dog after application. Some dogs may experience temporary startle effects when any product is applied. Dogs may experience some temporary irritation at the site of product application such as redness, scratching or other signs of discomfort. If signs of sensitivity occur, bathe your dog with a mild soap and rinse with large amounts of water. If these or other side effects occur, consult your veterinarian or call 1-888-908-Tick (8425). If your dog has an unusual reaction to the initial application, consult a veterinarian before repeating application. The most common signs of incidental ingestion are excessive salivation and foaming at the mouth. If these symptoms occur, immediately feed your dog and continue to monitor your dog for the next 24 hours. Do not use on cats. Keep cats away from treated dogs for 24 hours. If applied to a cat or ingested by a cat, contact your veterinarian.

2. Sentinel Flavor Tabs for Dogs – 11-25 lbs – 6 Count

Sentinel Flavor Tabs for Dogs - 11-25 lbs - 6 Count

  • Protects your dog against heartworm disease and intestinal worms
  • Easy to administer tablet also helps control fleas
  • Palatable beef-flavored tablets taste like treats

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Product Details

Specifications

Details
For Use With Dogs
Administration Form Oral
Breed Size Small Breeds
Product Form Tablet
Strength 5.75 mg Milbemycin Oxime and 115 mg Lufenuron
Drug Type Parasiticide

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3. Heartgard Tablets 26-50 lbs, 6 Month Supply

Heartgard Tablets 26-50 lbs, 6 Month Supply

  • 26-50 lbs

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Product Details

Specifications

Details
For Use With Dogs – 6 weeks or older
Administration Form Oral
Breed Size Medium Breeds
Product Form Chew
Strength 136 mcg Ivermectin and 114 mg Pyrantel

4. Intervet Safe-Guard Canine Dewormer – 3 pack, 1 g packets

Intervet Safe-Guard Canine Dewormer - 3 pack, 1 g packets

  • Mix with food
  • Comes in three day convenient doses
  • Safe and effective
  • Treats and controls tapeworms, roundworms, hookworms, and whipworms
  • No prescription needed

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Specifications

Details
Units in Package 3
Unit Size 1 g packets
Indications For the treatment and control of roundworms (toxocara canis, toxascaris leonina), hookworms (ancylostomia canium, uncinaria stenocephala), whipworms (trichuris vulpis), and tapeworms (taenia pisiformis).
Directions Consult your veterinarian for assistance in the diagnosis, treatment, and control of parastism. The daily dose is mg/kg (22.7 mg/lb) of body weight. Please refer to the following dosing table for help in finding the right dose for your dog. Dosing Table: 10 pounds: 1 gram, 20 pounds: 2 grams, 30 pounds: 1 gram, 40 pounds: 4 gram, 50 pounds: 1 gram plus 4 gram, 60 pound: 2 gram plus 4 grams, 80 pounds: two 4 gram, over 80 pounds: use combinations to obtain recommended daily dose. Packet size is the daily dose. the dog must be treated wit this dose 3 days in a row. You should weigh your dog to make sure you are using the right size and number of packets. If your dog’s weight is in – between the suggested dosing sizes. It is safe to use the next higher size. For example, a 15-pound dog should be treated with the 2-gram packet. Give to your dog by mixing the daily dose with a small amount of the usual food. Make sure your dog eats all of the medicated food. You may need to moisten dry dog food to aid mixing. Repeat the daily dose for three days in row. Deworming schedules may vary depending on the climate where you live and the activity of our dog. The following schedule should be used as general guidance. Newly weaned pups (6 to 8 weeks of age). should be dewormed at 6, 8, 10 and 12 weeks of Age. Treat the dam at the same time as the puppies, dogs over six months of age should be dewormed. at least twice each year. Each deworming requires 3 daily treatments. Storage: Store at controlled room temperature.
Warnings Keep this and all medications out of the reach of children. In US clinical studies 3 of 240 dogs (about 1% of the treated dogs) had vomiting associated with use of this product. When using this product: Safe-Guard Canine is safe for use in puppies 6 weeks or older and adult dogs, including pregnant bitches. Do not deworm a dog or puppy that is sick. Consult your veterinarian for diagnosis of the illness.

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KGAZ
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5. Heartgard Plus for Dogs – 26-50 lbs (1 Chew)

Heartgard Plus for Dogs - 26-50 lbs (1 Chew)

  • 26-50 lbs

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6. Bayer K9 Advantix II Flea and Tick Prevention for Large Dogs, 21-55 lbs, 4 Doses

Bayer K9 Advantix II Flea and Tick Prevention for Large Dogs, 21-55 lbs, 4 Doses

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Product Details

Specifications

Details
Holds up to 55.0 Pounds
Intended Pet Type Dog
Application Type Topical
Used For Pest Repellent, Pest Elimination
Treats and/or Prevents Against Fleas, Ticks
Product Form Oil
Duration 1 Months
Package Quantity 4
Minimum Weight Capacity 21.0 Pounds
Pet Lifestage All Ages
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7. Trifexis Chewable Tablets for Dogs 20.1-40 lbs Green, Size: 12 Count | PetSmart

Trifexis Chewable Tablets for Dogs 20.1-40 lbs Green, Size: 12 Count | PetSmart

  • 12 Count

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8. Interceptor Rx, 2-10 lbs Dog, Brown, 6 Count

Interceptor Rx, 2-10 lbs Dog, Brown, 6 Count

  • 2-10 lbs

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Heartland Veterinary Supply and Pharmacy
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Product Details

Specifications

Details
For Use In dogs and cats

9. Iverhart Plus for Dogs 1-25 lbs, Blue, 6 Pack

Iverhart Plus for Dogs 1-25 lbs, Blue, 6 Pack

  • 1-25 lbs

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Amanda T
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10. Interceptor Plus Chewables for Dogs 25.1-50 lbs, 12 Month Supply

Interceptor Plus Chewables for Dogs 25.1-50 lbs, 12 Month Supply

  • 25.1-50 lbs

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PetMeds

Product Details

Specifications

Details
For Use With Dogs
Administration Form Oral
Breed Size Medium Breeds
Product Form Chew
Strength 11.5 mg Milbemycin Oxime and 114 mg Praziquantel

11. Sentinel Flavor Tabs for Dogs 51-100 lbs, 6 Month Supply

Sentinel Flavor Tabs for Dogs 51-100 lbs, 6 Month Supply

  • White

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Revival Animal Health

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Specifications

Details
Weight and Color 51-100 lbs White

12. Iverhart Plus Flavored Chewables for Dogs 51-100 lbs, 6 Month Supply

Iverhart Plus Flavored Chewables for Dogs 51-100 lbs, 6 Month Supply

  • 51-100 lbs, 6 Month

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Arkangel
David H

13. Sentinel Spectrum for Dogs – 8-25 lbs – 6 Count

Sentinel Spectrum for Dogs - 8-25 lbs - 6 Count

  • 8-25 lbs

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Revival Animal Health
petvm.com

Product Details

Specifications

Details
Primary Brand Sentinel Spectrum
For Pet Weight Max 25 LBS
For Pet Weight Min 8.1 LBS

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Melissa Crozier

14. Tri-Heart Plus Chewable Tablets for Dogs, 26-50 lbs

Tri-Heart Plus Chewable Tablets for Dogs, 26-50 lbs

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15. Revolution for Dogs 0-5 lbs 6 Doses by Zoetis

Revolution for Dogs 0-5 lbs 6 Doses by Zoetis

  • Eliminates fleas treatment and prevention
  • Tick Control
  • Dog Flea Tablets

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16. Interceptor Brown, Dogs 2-10 lbs. 12 Month Supply

Interceptor Brown, Dogs 2-10 lbs. 12 Month Supply

  • Interceptor is contraindicated in animals with a history of an allergic reaction to milbemycin. Keep out of reach of children.
  • Possible side effects.
  • If you miss giving a dose, give it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Do not double the dose.

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Review Date 7/8/2012

17. Sentinel Spectrum 2-8 lbs, 6 Month Supply

Sentinel Spectrum 2-8 lbs, 6 Month Supply

  • 2-8 lbs

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18. Simparica Trio Chewable Tablets 44.1-88 lbs 1 Dose

Simparica Trio Chewable Tablets 44.1-88 lbs 1 Dose

  • (44.1-88 lbs), 6

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Boo Ba Loo

19. Heartgard Plus Chewables 1pk Green 26-50lbs for Dogs

Heartgard Plus Chewables 1pk Green 26-50lbs for Dogs

  • 26-50 lbs., 1 Month

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20. Tri-Heart Plus for Dogs 26-50 lbs Green 12ct

Tri-Heart Plus for Dogs 26-50 lbs Green 12ct

  • 26-50 lbs

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EDWARD

Conclusion

The best way to prevent fleas and heartworms in dogs is to use a combination of monthly topical spot-on treatments and oral chewable tablets. Some common brands of flea and heartworm prevention products for dogs include Frontline Plus, Advantage II, and Trifexis.

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