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20 Best Flea And Heartworm Medicine For Dogs (2022 Updated)

The purpose of flea and heartworm medicine for dogs is to protect them from these parasites. Fleas and heartworms can both cause serious health problems for dogs, so it is important to keep them away from your pet.

Flea and heartworm medicine usually come in the form of a monthly pill or topical treatment that you apply to your dog’s skin.

20 Best Flea And Heartworm Medicine For Dogs

Product Image Product Name Features Price

Iverhart Plus for Dogs 1-25 lbs, Blue, 6 Pack

  • 1-25 lbs

Novartis Sentinel Flavor Tabs for Dogs, 51-100 lbs – 6 pack

  • 51-100 lbs

Sentinel Flavor Tabs for Dogs 51-100 lbs, 6 Month Supply

  • White

Trifexis 6pk Dog 60.1-120 lbs by Lilly

  • 60.1-120 lbs

Interceptor Rx, 2-10 lbs Dog, Brown, 6 Count

  • 2-10 lbs

Trifexis for Dogs – 10.1-20 lbs (6 Chew Tabs)

  • 10.1-20 lbs

Heartgard Plus for Dogs

  • 6 count

Interceptor Plus Chewable for Dogs, Yellow 25.1-50 lbs 6 Doses

  • 25.1-50 lbs

Interceptor Brown, Dogs 2-10 lbs. 12 Month Supply

  • Interceptor is contraindicated in animals with a history of an allergic reaction to milbemycin. Keep out of reach of children.

Sentinel Spectrum for Dogs

  • 50.1-100 lbs

Heartgard Plus Chewables 1pk Blue 01-25lbs for Dogs

  • 01-25lbs

Revolution for Dogs

  • Revolution (Brown) for Small Dogs 5-10 kg (10.1 – 20 lbs).
  • Key Benefits.
  • Dosage and Administration.

Sentinel Spectrum 50.1-100 lbs, 6 Month Supply

  • 50.1-100 lbs

Trifexis Chewable Tablets for Dogs 20.1-40 lbs Green, Size: 3 Count | PetSmart

  • 3 Count
Iverhart Plus for Dogs 1-25 lbs, Blue, 6 Pack
  • 1-25 lbs
Novartis Sentinel Flavor Tabs for Dogs, 51-100 lbs – 6 pack
  • 51-100 lbs
Sentinel Flavor Tabs for Dogs 51-100 lbs, 6 Month Supply
  • White
Trifexis 6pk Dog 60.1-120 lbs by Lilly
  • 60.1-120 lbs
Interceptor Rx, 2-10 lbs Dog, Brown, 6 Count
  • 2-10 lbs
Trifexis for Dogs – 10.1-20 lbs (6 Chew Tabs)
  • 10.1-20 lbs
Heartgard Plus for Dogs
  • 6 count
Interceptor Plus Chewable for Dogs, Yellow 25.1-50 lbs 6 Doses
  • 25.1-50 lbs
Interceptor Brown, Dogs 2-10 lbs. 12 Month Supply
  • Interceptor is contraindicated in animals with a history of an allergic reaction to milbemycin. Keep out of reach of children.
Sentinel Spectrum for Dogs
  • 50.1-100 lbs
Heartgard Plus Chewables 1pk Blue 01-25lbs for Dogs
  • 01-25lbs
Revolution for Dogs
  • Revolution (Brown) for Small Dogs 5-10 kg (10.1 – 20 lbs).
  • Key Benefits.
  • Dosage and Administration.
Sentinel Spectrum 50.1-100 lbs, 6 Month Supply
  • 50.1-100 lbs
Trifexis Chewable Tablets for Dogs 20.1-40 lbs Green, Size: 3 Count | PetSmart
  • 3 Count

1. Iverhart Plus for Dogs 1-25 lbs, Blue, 6 Pack

Iverhart Plus for Dogs 1-25 lbs, Blue, 6 Pack

  • 1-25 lbs

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Chewy.com
Vetdepot.com
California Pet Pharmacy

Product Details

Reviews From Real Customers

Dane S.
Gail Coelho
Steven Brown

2. Novartis Sentinel Flavor Tabs for Dogs, 51-100 lbs – 6 pack

Novartis Sentinel Flavor Tabs for Dogs, 51-100 lbs - 6 pack

  • 51-100 lbs

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Chewy.com
Allivet Pet Pharmacy
PetMeds
PetCareRx

Product Details

Specifications

Details
For Use With Dogs
Administration Form Oral
Breed Size Medium Breeds, Large Breeds
Product Form Tablet
Strength 23 mg Milbemycin Oxime and 460 mg Lufenuron

Reviews From Real Customers

jenn.d
Renee' K.
kimbery.d

3. Tri-Heart Plus Chewable Tablets for Dogs, 26-50 lbs

Tri-Heart Plus Chewable Tablets for Dogs, 26-50 lbs

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Valley Vet Supply
Allivet Pet Pharmacy
PetMeds
Chewy.com

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Reviews From Real Customers

acf757
William Milan
DBGarrison

4. Trifexis 10.1-20 lbs for Dogs, 6 Chewable Tablets by EntirelyPets Pharmacy

Trifexis 10.1-20 lbs for Dogs, 6 Chewable Tablets by EntirelyPets Pharmacy

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Valley Vet Supply
VetRxDirect a Pet Pharmacy
California Pet Pharmacy
EntirelyPets Pharmacy

Product Details

Reviews From Real Customers

Pheeni Belinni
lacy.s
A veteran

5. Sentinel Flavor Tabs for Dogs 51-100 lbs, 6 Month Supply

Sentinel Flavor Tabs for Dogs 51-100 lbs, 6 Month Supply

  • White

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Valley Vet Supply
VetRxDirect a Pet Pharmacy
Revival Animal Health

Product Details

Specifications

Details
Weight and Color 51-100 lbs White

Reviews From Real Customers

Echotwo

6. Trifexis 6pk Dog 60.1-120 lbs by Lilly

Trifexis 6pk Dog 60.1-120 lbs by Lilly

  • 60.1-120 lbs

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PetCareRx
Valley Vet Supply
Allivet Pet Pharmacy
Petco.com

Product Details

Specifications

Details
Active Ingredient(s) Spinosad, milbemycin oxime

Reviews From Real Customers

Tee Are

7. Interceptor Rx, 2-10 lbs Dog, Brown, 6 Count

Interceptor Rx, 2-10 lbs Dog, Brown, 6 Count

  • 2-10 lbs

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Chewy.com
PetCareRx
Heartland Veterinary Supply and Pharmacy
KV Supply

Product Details

Specifications

Details
For Use In dogs and cats

Reviews From Real Customers

Larry F
Janice H

8. Trifexis for Dogs – 10.1-20 lbs (6 Chew Tabs)

Trifexis for Dogs - 10.1-20 lbs (6 Chew Tabs)

  • 10.1-20 lbs

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Revival Animal Health
Petco.com
Chewy.com
PetMeds

Product Details

9. Trifexis 5-10 lbs for Dogs, 6 Chewable Tablets by EntirelyPets Pharmacy

Trifexis 5-10 lbs for Dogs, 6 Chewable Tablets by EntirelyPets Pharmacy

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Valley Vet Supply
VetRxDirect a Pet Pharmacy

Product Details

Specifications

Details
Active Ingredient Trifexis Pink

10. Trifexis 20.1-40 lbs for Dogs, 6 Chewable Tablets by EntirelyPets Pharmacy

Trifexis 20.1-40 lbs for Dogs, 6 Chewable Tablets by EntirelyPets Pharmacy

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Valley Vet Supply
Allivet Pet Pharmacy
Chewy.com
VetRxDirect a Pet Pharmacy

Product Details

Specifications

Details
For Use With Dogs
Administration Form Oral
Breed Size Small Breeds, Medium Breeds
Product Form Chewable Tablet
Strength 560 mg Spinosad and 9.3 mg Milbemycin Oxime

11. Heartgard Plus for Dogs

Heartgard Plus for Dogs

  • 6 count

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Allivet Pet Pharmacy
Revival Animal Health
Chewy.com
PetCareRx

Product Details

Specifications

Details
For Use With Dogs – 6 weeks or older
Administration Form Oral
Breed Size Extra Small Breeds, Small Breeds
Product Form Chew
Strength 68 mcg Ivermectin and 57 mg Pyrantel

Reviews From Real Customers

Brittany Jacobs
Jahlies
HappyPetParent

12. Interceptor Plus Chewable for Dogs, Yellow 25.1-50 lbs 6 Doses

Interceptor Plus Chewable for Dogs, Yellow 25.1-50 lbs 6 Doses

  • 25.1-50 lbs

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Allivet Pet Pharmacy
Chewy.com
petvm.com
Valley Vet Supply

Product Details

Specifications

Details
For Use With Dogs
Administration Form Oral
Breed Size Medium Breeds
Product Form Chew
Strength 11.5 mg Milbemycin Oxime and 114 mg Praziquantel

Reviews From Real Customers

Oceanna Cruise
Karen Gilbert
kensch888

13. Interceptor Brown, Dogs 2-10 lbs. 12 Month Supply

Interceptor Brown, Dogs 2-10 lbs. 12 Month Supply

  • Interceptor is contraindicated in animals with a history of an allergic reaction to milbemycin. Keep out of reach of children.
  • Possible side effects.
  • If you miss giving a dose, give it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Do not double the dose.

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PetCareRx
Allivet Pet Pharmacy
Vetdepot.com
California Pet Pharmacy

Product Details

Specifications

Details
Review Date 7/8/2012

14. Sentinel Spectrum for Dogs

Sentinel Spectrum for Dogs

  • 50.1-100 lbs

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PetMeds
PetCareRx
Jefferspet.com
Vet Approved RX

Product Details

Reviews From Real Customers

nikki.j
mic.v
YeCats

15. Tri-Heart Plus Chewable Tablets for Dogs, 1-25 lbs

Tri-Heart Plus Chewable Tablets for Dogs, 1-25 lbs

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Valley Vet Supply
Allivet Pet Pharmacy
PetMeds
Chewy.com

Product Details

Reviews From Real Customers

Shelly
SuwanneeGal

16. Heartgard Plus Chewables 1pk Blue 01-25lbs for Dogs

Heartgard Plus Chewables 1pk Blue 01-25lbs for Dogs

  • 01-25lbs

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PetCareRx
Chewy.com
PetMeds

Product Details

Reviews From Real Customers

ActionJaxson

17. Revolution for Dogs

Revolution for Dogs

  • 10.1-20 lbs, 6 Month

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Valley Vet Supply
FarmVet.com
petvm.com
PetCareRx

Product Details

Reviews From Real Customers

Star 27

18. Simparica Trio for Dogs 5.6-11 lbs, 6 Chewables

Simparica Trio for Dogs 5.6-11 lbs, 6 Chewables

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Allivet Pet Pharmacy
Valley Vet Supply
PetCareRx
petvm.com

Product Details

Reviews From Real Customers

DaisysMom
LexYve93
Heather B.

19. Sentinel Spectrum 50.1-100 lbs, 6 Month Supply

Sentinel Spectrum 50.1-100 lbs, 6 Month Supply

  • 50.1-100 lbs

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Allivet Pet Pharmacy
Valley Vet Supply
VetRxDirect a Pet Pharmacy

Product Details

Reviews From Real Customers

NANCY F
Brandy B
Lenna

20. Trifexis Chewable Tablets for Dogs 20.1-40 lbs Green, Size: 3 Count | PetSmart

Trifexis Chewable Tablets for Dogs 20.1-40 lbs Green, Size: 3 Count | PetSmart

  • 3 Count

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Allivet Pet Pharmacy

Product Details

Conclusion

There are a variety of flea and heartworm medicines available for dogs. The best course of action is to speak to a veterinarian to determine which medicine is best for your dog.

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