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20 Best Chemicals For Bed Bugs (2022 Updated)

There are a variety of chemicals that can be used to kill bed bugs. The most common are insecticides, which are applied directly to the bugs themselves. These can be in the form of aerosable sprays, gels, or powders.

Insecticides work by either killing the bugs outright, or by causing them to dehydrate and die.

Other chemicals that can be used to control bed bugs include dusts, baits, and traps. Dusts are usually made of silica or diatomaceous earth, and work by physically abrasive the bed bugs when they come into contact with it.

This will usually kill them outright. Baits and traps work by luring the bugs into a space where they can be killed or removed. These can be either physical traps, or chemical traps that use pheromones to attract the bugs.

20 Best Chemicals For Bed Bugs

Product Image Product Name Features Price

Crossfire Bed Bug Concentrate 13oz

  • Bottle (13 oz)

JT Eaton Kills Bedbugs II Spray, 1 gal.

  • Indoor and outdoor use
  • Can be sprayed directly on mattress
  • Lasts up to 16 weeks

Cimexa Insecticide Dust – 4oz

  • 4 oz

EcoSmart Bed Bug Killer, Organic – 14 oz

  • Special mattress/carpet applicator to penetrate tufts and piles.
  • Kills adult bed bugs, all stages of larva and bed bug eggs.

Ortho 0212710 Home Defense Max Bed Bug Killer, 1 Gallon

  • 1 Gallon

Harris Egg Kill & Resistant Bed Bug Killer (16oz)

  • Kills bed bugs and their eggs that have become resistant to pyrethroid
  • Easy to use spray
  • Treats mattresses bed frames headboards floors carpeting baseboards furniture moldings and walls

Sprayway Dust Mite & Bed Bug Killer, Good Night – 16 oz

  • 16 oz

Hygea Natural Bed Bug Exterminator Spray 24 oz

  • Ready to Use.
  • TSA permissible carry on.
  • Manufactured in the USA.

7 Ounce JT Eaton Bedbug Powder

  • Active ingredient is diatomaceous earth
  • 12 bottles per case
  • Insects never become resistant to the powder

Harris BLKBB-32 Bed Bug Killer, 32 oz

  • 32 oz

Harris Large Bed Bug Kit

  • Bed Bug Traps; EGG-16 (SKU 7298862)
  • Egg Kill bed bug killer; HBB-128 (SKU 7247604)
  • Bed Bug killer gallon; and HDE-8 (SKU 7300080) Diatomaceous earth Bed Bug killer

Ecoraider – Bed Bug Killer Sprayer – 16 oz – Natural & Non-Toxic

  • Spray Bottle (16 oz)

Harris Bed Bug Killer Powder 8 oz

  • 8 oz

Suspend SC Insecticide

  • Broad-spectrum control of more than 50 nuisance pests
  • Works at low and high concentrations
  • No visible residue

Ecoraider – Bed Bug Killer – 1 Gallon Jug – Natural & Non-Toxic

  • 1 Gallon Jug

PT Alpine Flea & Bed Bug Insecticide – 20 oz.

  • Safe for Pets.
  • Kills fleas for up to 30 days, Kills hatching flea eggs for up to 7 months, Kills bed bugs, Aids in preventing bed bug hatch.

Ortho Home Defense Bed Bug Killer Liquid 24 oz

  • Size : 24 oz
  • Pest Type : Bed Bugs, Fleas/Ticks
  • Active Ingredient : Sumithrin, Imidacloprid

JT Eaton 17.5 oz. Aerosol Spray Bedbug Killer Plus 217

  • 17.5 oz

Bed Bug Patrol | Bed Bug Killer Spray Treatment |1 Gallon – Bed Bug Killer Value Pack

  • Trap the Bed Bugs – Install Bed Bug Traps (tacky side up) below furniture, anywhere legs or feet of furniture touch the ground.

Bed Bug Killer 16oz Ready-to-Use Spray | by NaturesMace

  • 16 oz
Crossfire Bed Bug Concentrate 13oz
  • Bottle (13 oz)
JT Eaton Kills Bedbugs II Spray, 1 gal.
  • Indoor and outdoor use
  • Can be sprayed directly on mattress
  • Lasts up to 16 weeks
Cimexa Insecticide Dust – 4oz
  • 4 oz
EcoSmart Bed Bug Killer, Organic – 14 oz
  • Special mattress/carpet applicator to penetrate tufts and piles.
  • Kills adult bed bugs, all stages of larva and bed bug eggs.
Ortho 0212710 Home Defense Max Bed Bug Killer, 1 Gallon
  • 1 Gallon
Harris Egg Kill & Resistant Bed Bug Killer (16oz)
  • Kills bed bugs and their eggs that have become resistant to pyrethroid
  • Easy to use spray
  • Treats mattresses bed frames headboards floors carpeting baseboards furniture moldings and walls
Sprayway Dust Mite & Bed Bug Killer, Good Night – 16 oz
  • 16 oz
Hygea Natural Bed Bug Exterminator Spray 24 oz
  • Ready to Use.
  • TSA permissible carry on.
  • Manufactured in the USA.
7 Ounce JT Eaton Bedbug Powder
  • Active ingredient is diatomaceous earth
  • 12 bottles per case
  • Insects never become resistant to the powder
Harris BLKBB-32 Bed Bug Killer, 32 oz
  • 32 oz
Harris Large Bed Bug Kit
  • Bed Bug Traps; EGG-16 (SKU 7298862)
  • Egg Kill bed bug killer; HBB-128 (SKU 7247604)
  • Bed Bug killer gallon; and HDE-8 (SKU 7300080) Diatomaceous earth Bed Bug killer
Ecoraider – Bed Bug Killer Sprayer – 16 oz – Natural & Non-Toxic
  • Spray Bottle (16 oz)
Harris Bed Bug Killer Powder 8 oz
  • 8 oz
Suspend SC Insecticide
  • Broad-spectrum control of more than 50 nuisance pests
  • Works at low and high concentrations
  • No visible residue
Ecoraider – Bed Bug Killer – 1 Gallon Jug – Natural & Non-Toxic
  • 1 Gallon Jug
PT Alpine Flea & Bed Bug Insecticide – 20 oz.
  • Safe for Pets.
  • Kills fleas for up to 30 days, Kills hatching flea eggs for up to 7 months, Kills bed bugs, Aids in preventing bed bug hatch.
Ortho Home Defense Bed Bug Killer Liquid 24 oz
  • Size : 24 oz
  • Pest Type : Bed Bugs, Fleas/Ticks
  • Active Ingredient : Sumithrin, Imidacloprid
JT Eaton 17.5 oz. Aerosol Spray Bedbug Killer Plus 217
  • 17.5 oz
Bed Bug Patrol | Bed Bug Killer Spray Treatment |1 Gallon – Bed Bug Killer Value Pack
  • Trap the Bed Bugs – Install Bed Bug Traps (tacky side up) below furniture, anywhere legs or feet of furniture touch the ground.
Bed Bug Killer 16oz Ready-to-Use Spray | by NaturesMace
  • 16 oz

1. Crossfire Bed Bug Concentrate 13oz

Crossfire Bed Bug Concentrate 13oz

  • Bottle (13 oz)

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DoMyOwn.com

Product Details

Specifications

Details
Restricted Use No
Application Equipment Backpack Sprayer, Gloves, Pump Sprayer
Application Methods Crack & Crevice, Spot Treatment
Chemical Type Pyrethroid
Formulation Suspended Concentrate

Reviews From Real Customers

Jennifer Johnson
Woody
OverDose665 22

2. JT Eaton Kills Bedbugs II Spray, 1 gal.

JT Eaton Kills Bedbugs II Spray, 1 gal.

  • Indoor and outdoor use
  • Can be sprayed directly on mattress
  • Lasts up to 16 weeks

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Amazon.com
Walmart
Ace Hardware
WebstaurantStore.com

Product Details

Specifications

Details
Item is Shipped at this Packaging Level Y
Information Effective Date 3/20/2010 12:00:00 AM
Packaging Depth 3.125 IN
Packaging Height 12 IN
Packaging Width 7.875 IN

Reviews From Real Customers

Jason
Koko
Relieved

3. Cimexa Insecticide Dust – 4oz

Cimexa Insecticide Dust - 4oz

  • 4 oz

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Amazon.com
eBay
Walmart – USA Supply
DoMyOwn.com

Product Details

Specifications

Details
Restricted Use No
Application Equipment Duster
Application Methods Crack & Crevice, Injection, Spot Treatment
Active Ingredient Amorphous Silica Gel 100%
Chemical Type Organic

Reviews From Real Customers

mania-51
zz747
THEODORA

4. EcoSmart Bed Bug Killer, Organic – 14 oz

EcoSmart Bed Bug Killer, Organic - 14 oz

  • Special mattress/carpet applicator to penetrate tufts and piles.
  • Kills adult bed bugs, all stages of larva and bed bug eggs.
  • Proven effective on even pesticide resistant strains of bed bugs.
  • Safe to use around children and pets.
  • Pleasant low-fragrance formula.

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Tractor Supply Company
Lowe’s
The BuildClub

Product Details

Specifications

Details
Units in Package 1
Unit Size 14 oz
Directions Shake well before using. Read entire label and use accordingly. For Best Results: Vacuum infested room thoroughly including mattress, foundation/box springs and upholstered furniture before using this product. Vacuum the carpet/rugs/flooring, especially where the carpet/flooring meets the wall near the head of the bed. Take vacuum cleaner bag to the outdoor trash immediately. For Mattress Applications: Remove all bedding and wash in hot water. Remove the mattress and box spring from bed. Hold can 6 inches from mattress and spray across all folds, tufts, seams and edging until damp. Also spray the seams and underside of the box spring. Allow mattress and box springs to dry completely before placing back on bed and putting on bedding. Repeat as necessary. For Carpet/Rug Applications: Hold can 2 feet from floor and spray carpet/rug using a smooth back and forth sweeping motion. Focus on areas where bed bugs may hide or rest. Spray entire carpet in room. The critical areas are carpeting/rugs adjacent and under the bed. Spray until damp. Avoid over-wetting or saturating carpets/rugs. Allow carpet/rugs to dry completely and vacuum again. Repeat as necessary. Note: Effective bed bug control typically requires thorough and multiple applications. Visit www.ecosmart.com for more information. This product contains plant oils which are inherently fragrant For people who are fragrance or plant oil sensitive, test a small application before using over a larger area. While staining is unlikely, as with most household products it is recommended to test for staining on an inconspicuous area of all surfaces to be sprayed before using. Wipe away excess product on furniture immediately after application. To prevent slipping on hard surfaces, wipe away excess product with a damp cloth.
Ingredients Active Ingredients: 2-Phenethyl Propionate (3.0%), Peppermint Oil (1.5%), Rosemary Oil (1.5%). Other Ingredients (Water, 2-Propanol, Wintergreen Oil, White Mineral Oil, Polyglyceryl Oleate, Sodium Benzoate, Nitrogen): (94.0%). Total: (100.0%).
Warnings Precautionary Statements: We recommend good safety practices when using any insecticide, such as avoiding contact with eyes and skin and keeping out of the reach of children. If product gets in eyes, flush with water for at least 15 minutes. If on skin, wash with soap and water. If irritation persists, contact a physician. Physical Hazards: Contents under pressure. Keep away from heat, sparks and open flames. Do not puncture or incinerate container. Exposure to temperatures above 130 degrees Fahrenheit may cause container to burst Storage & Disposal: Store in a cool, dry area away from heat or open flame. When container is empty, offer for recycling if available or discard in trash. Limitation of Liability: To the extent consistent with applicable law, EcoSmart makes no warranties of merchantability or of fitness for a particular purpose, nor any other express or implied warranty except as stated above. Buyer assumes all responsibility for safety and use not in accordance with label, directions and precautionary statements.

Reviews From Real Customers

SuzQ
DH Pa mom
Lori31268

5. Ortho 0212710 Home Defense Max Bed Bug Killer, 1 Gallon

Ortho 0212710 Home Defense Max Bed Bug Killer, 1 Gallon

  • 1 Gallon

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Product Details

Specifications

Details
Brand Name Ortho
Product Type Bed Bug Killer
Indoor or Outdoor Indoor
Product Form Liquid
Safe for Edibles No

Reviews From Real Customers

Matt Haw
Firekiller91
Weak Hands-no grip

6. Harris Egg Kill & Resistant Bed Bug Killer (16oz)

Harris Egg Kill & Resistant Bed Bug Killer (16oz)

  • Kills bed bugs and their eggs that have become resistant to pyrethroid
  • Easy to use spray
  • Treats mattresses bed frames headboards floors carpeting baseboards furniture moldings and walls
  • Spot treat luggage closets drapes and other window or wall treatments
  • Product is applicable for the following pest types: bed bugs

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Home Depot

Product Details

Specifications

Details
Weight 1.13 oz

Reviews From Real Customers

C Heisler
Begonial
Benedict

7. Sprayway Dust Mite & Bed Bug Killer, Good Night – 16 oz

Sprayway Dust Mite & Bed Bug Killer, Good Night - 16 oz

  • 16 oz

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Amazon.com – Seller
Blain’s Farm & Fleet
Valu Home Centers
Sprayway

Product Details

Specifications

Details
Units in Package 1
Unit Size 16 oz
Directions It is a federal law violation to use this product in a manner inconsistent with its labeling. Shake well before each use. remove protective cap. Aim spray away from person. Push button to spray. To Kills Dust Mites: First thoroughly vacuum entire room concentrating on areas where dust mites congregate, such as mattresses, box spring, headboards, walls, floors, carpeting, and baseboards. Then spray surfaces until damp. On mattresses allow spray to dry thoroughly before replacing bedding. To Kill Bedbugs: Apply as a spot treatment to cracks and crevices around baseboards, floorboards, headboards, and walls. First thoroughly clean and air mattresses and springs. Then spot treat only areas that may harbor pests. On mattresses concentrate on tufts, folds. Repeat as necessary. To Kill Ticks and Fleas: Spray around beds, furniture and pet’s habitat. Spray pet sleeping quarters, bedding, floor, and floor covering where pets are kept. Repeat as necessary. Use only a recommended pet spray on pets. To Kill Lice: Spray in an inconspicuous area to test for possible staining or discoloration. Inspect again after drying and then proceed to spray entire area to be treated. Hold container upright with nozzle away from you. Depress valve and spray from a distance of 8 to 10 inches. Spray each square foot for 5 seconds or until damp. Spray only home garments, parts of bedding, including mattresses and furniture that cannot be either laundered or dry-cleaned. Allow spray articles to dry thoroughly before use. Storage and Disposal; Do not contaminate water, food or feed by storage or disposal. Storage: Store in a secure, preferably locked storage area that is cool and dry. Disposal: Do not puncture or incinerate. If Empty: Place in trash or offer for recycling if available. If Partly Filled: Call your local solid waste agency for disposal instructions. 24 Hour medical emergency: 866-836-8855.
Warnings First Aid – If in Eyes: Hold eye open and rinse slowly and gently with water for 15-20 minutes. remove contact lenses, if present, after the first 5 minutes, then continue rinsing eyes. If on Skin or Clothing: Take off contaminated clothing. Rinse skin immediately with plenty of water for 15-20 minutes. If Swallowed: Call a poison control center or doctor immediately for treatment advice. Have person sip a glass of water if able to swallow. Do not induce vomiting unless told to do so by a poison control center or doctor. Do not give anything by mouth to an unconscious person. Call a poison control center or doctor for treatment advice. Have the product container or label with you when calling a poison control center or doctor, or going for treatment. For information regarding medical emergencies or incidents, call 866-836-8855. Precautionary Statements: Hazardous to humans and domestic animals. Caution: Harmful if absorbed through skin. Avoid contact with eyes, skin or clothing. Wash hands before eating, drinking, chewing gum, using tobacco or using the toilet. Do not use in commercial food/feed processing, preparation food/feed storage or serving areas. In the home all food/feed processing surfaces and utensils should be covered during treatment, or thoroughly washed before use. Exposed food/feed should be covered or removed. Remove pets, birds and cover fish aquarium before spraying. Environmental Hazards: This product is toxic to fish and other aquatic invertebrates. Do not apply directly to water. Do not contaminate water by cleaning of equipment or disposal of wastes. Physical or Chemical Hazards: Contents under pressure. Do not use or store near heat or open flame. Do not puncture or incinerate container. Exposure to temperatures above 130 degrees F may cause bursting. This product is not for use on humans. If lice infestation should occur on humans, use a product labeled for use on humans. Vacate room after treatment and ventilate before reoccupying. Do not allow children or pets to contact treated areas until surfaces are dry.

Reviews From Real Customers

hurtzdonut
tweeders2011
Tweeders2011

8. Hygea Natural Bed Bug Exterminator Spray 24 oz

Hygea Natural Bed Bug Exterminator Spray 24 oz

  • Ready to Use.
  • TSA permissible carry on.
  • Manufactured in the USA.
  • Safe to use around children and pets.
  • Box springs.

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Product Details

Specifications

Details
Spray Application Type Trigger
Concentrated or Ready to Use Ready to use
Application Type Spray
Safe for Edibles No
Garden Pest Location Not for Garden Use

Reviews From Real Customers

Kathryn
Chuttraporn M.

9. 7 Ounce JT Eaton Bedbug Powder

7 Ounce JT Eaton Bedbug Powder

  • Active ingredient is diatomaceous earth
  • 12 bottles per case
  • Insects never become resistant to the powder
  • This product is applicable for the following pest types: Ants Bed Bugs Roaches Crickets Fleas Ticks

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Valu Home Centers
Grainger Industrial Supply

Product Details

Specifications

Details
Item is Shipped at this Packaging Level N
Information Effective Date 3/27/2010 12:00:00 AM
Packaging Depth 3.5 IN
Packaging Height 11 IN
Packaging Width 3.5 IN

Reviews From Real Customers

Vanessa
lenvegas2012
Trista R.

10. Harris BLKBB-32 Bed Bug Killer, 32 oz

Harris BLKBB-32 Bed Bug Killer, 32 oz

  • 32 oz

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Tractor Supply Company

Product Details

Specifications

Details
Weight 2.2 oz

Reviews From Real Customers

Chastev
ShawnML

11. Harris Large Bed Bug Kit

Harris Large Bed Bug Kit

  • Bed Bug Traps; EGG-16 (SKU 7298862)
  • Egg Kill bed bug killer; HBB-128 (SKU 7247604)
  • Bed Bug killer gallon; and HDE-8 (SKU 7300080) Diatomaceous earth Bed Bug killer

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Home Depot

Product Details

Specifications

Details
Spray Application Type Trigger
Concentrated or Ready to Use Ready to use
Application Type Spray
Safe for Edibles No
Pest Common Name Bed Bug

Reviews From Real Customers

TNH77
Gab
1bikerchick4god

12. Ecoraider – Bed Bug Killer Sprayer – 16 oz – Natural & Non-Toxic

Ecoraider - Bed Bug Killer Sprayer - 16 oz - Natural & Non-Toxic

  • Spray Bottle (16 oz)

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Home Depot

Product Details

Specifications

Details
Dimensions (Overall) 10 Inches (H) x 2.5 Inches (W) x 2.5 Inches (D)
Indoor/Outdoor Indoor
Treats and/or Prevents Against Bed Bugs
Product Form Liquid
Duration 2 weeks

Reviews From Real Customers

suzpit-66
leylus8
patrickbatman

13. Harris Bed Bug Killer Powder 8 oz

Harris Bed Bug Killer Powder 8 oz

  • 8 oz

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Walmart
Arbico Organics
Lowe’s

Product Details

Specifications

Details
Brand Name Harris
Organic No
Product Form Powder
Pest Type Bed Bugs
Safe for Edibles No

14. Suspend SC Insecticide

Suspend SC Insecticide

  • Broad-spectrum control of more than 50 nuisance pests
  • Works at low and high concentrations
  • No visible residue
  • Works on porous surfaces
  • For Residential, Industrial and Institutional Control of Major Nuisance Pests Listed on The Label

Product Details

Specifications

Details
Restricted Use No
Application Equipment Backpack Sprayer, Hose End Sprayer, Pump Sprayer
Application Methods Broadcast Spray, Crack & Crevice, Spot Treatment
Active Ingredient Deltamethrin 4.75%
Chemical Type Pyrethroid

Reviews From Real Customers

Earle
S
Ashley M

15. Ecoraider – Bed Bug Killer – 1 Gallon Jug – Natural & Non-Toxic

Ecoraider - Bed Bug Killer - 1 Gallon Jug - Natural & Non-Toxic

  • 1 Gallon Jug

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EcoVenger

Product Details

Specifications

Details
Dimensions (Overall) 10 Inches (H) x 7 Inches (W) x 5 Inches (D)
Indoor/Outdoor Indoor
Treats and/or Prevents Against Bed Bugs
Product Form Liquid
Duration 2 weeks

Reviews From Real Customers

Claudia
Amanda
Christine

16. PT Alpine Flea & Bed Bug Insecticide – 20 oz.

PT Alpine Flea & Bed Bug Insecticide - 20 oz.

  • Safe for Pets.
  • Kills fleas for up to 30 days, Kills hatching flea eggs for up to 7 months, Kills bed bugs, Aids in preventing bed bug hatch.
  • Prallethrin for quick knockdown.Long-lasting IGR pyriproxyfen kills hatching eggs for up to seven months.
  • 20 Oz Can Treats 2,625 square feet.
  • Use In: Apartments, Commercial Structures, Homes, Hotels, Kennels, Motels and Veterinary.

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Winfield United Professional

Product Details

Specifications

Details
Primary Pest Fleas
Utility Aerosol
Container Size 20 oz can
Case Amount 12x20oz
Application Amount See label for details

Reviews From Real Customers

65goldielocks
veg2go
isis68bc

17. Ortho Home Defense Bed Bug Killer Liquid 24 oz

Ortho Home Defense Bed Bug Killer Liquid 24 oz

  • Size : 24 oz
  • Pest Type : Bed Bugs, Fleas/Ticks
  • Active Ingredient : Sumithrin, Imidacloprid
  • Liquid form
  • For Indoor use

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Amazon
Ace Hardware
Max Warehouse
Life and Home

Product Details

Specifications

Details
Concentrated or Ready to Use Ready to Use
Organic No
Safe for Children and Pets No
Product Form Liquid
Product Type Bed Bug Killer

Reviews From Real Customers

Debra
J
Pamela

18. JT Eaton 17.5 oz. Aerosol Spray Bedbug Killer Plus 217

JT Eaton 17.5 oz. Aerosol Spray Bedbug Killer Plus 217

  • 17.5 oz

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Amazon
WebstaurantStore.com
Tractor Supply Company
Zoro

Product Details

Specifications

Details
Country of Origin Made in USA
Application Method Sprayer
Area Of Use Home
Concentrated or Ready to Use Ready to Use
Form Liquid

Reviews From Real Customers

pedroconejo
Twins A.
Donna

19. Bed Bug Patrol | Bed Bug Killer Spray Treatment |1 Gallon – Bed Bug Killer Value Pack

Bed Bug Patrol | Bed Bug Killer Spray Treatment |1 Gallon - Bed Bug Killer Value Pack

  • Trap the Bed Bugs – Install Bed Bug Traps (tacky side up) below furniture, anywhere legs or feet of furniture touch the ground.
  • Follow Up in 2 Weeks – Repeat steps if bed bugs are persisting.
  • Material Safety Data Sheet.

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Amazon
Walmart – Natures Innovation, Inc.
BedBugStore.com

Product Details

Reviews From Real Customers

Merky
Barbara W.
Andrea S.

20. Bed Bug Killer 16oz Ready-to-Use Spray | by NaturesMace

Bed Bug Killer 16oz Ready-to-Use Spray | by NaturesMace

  • 16 oz

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Amazon
Nature’s Mace

Product Details

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Deborah R.
ROSE A.
Russell S.

Conclusion

The most effective way to get rid of bed bugs is to contact a professional pest control company. They will be able to identify the problem and provide the best solution for your particular situation.

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